Recover from Trauma with Large Doses of Rejuvenate!™

Fred Liers PhDNearly two years ago, I was involved in a high-speed automobile accident. I was driving with my family on a major road when suddenly we were struck head on by a Jeep Cherokee SUV whose driver failed to yield on a green light, and fatefully crossed our path while making a left turn.

I escaped with minor injuries, except for a torn anterior cruciate ligament (ACL) in my right knee. Technically, the diagnosis was a torn ligament with deep bone bruising, a fractured tibia, and a torn meniscus. The doctor recommended surgery to “reconstruct” my ACL using one of my own hamstring ligaments.

As it turned out, one of the first health professionals to look at my knee (after the ER doctor) was a bodyworker friend. He worked on me for several hours. At some point, he re-aligned the chondials in my knee. Before that I could not walk. So, I was quite fortunate since I could now at least get around, first with crutches, and then without them.

Surgery would be postponed for six months partly because I could not afford down time away from teaching my university classes until the semester was complete. Also, my knee bruising was so deep that the swelling would take months to disappear completely (a condition for surgery).

I seriously considered avoiding surgery. I hoped to heal my knee using nutrition and rehabilitation alone. Yet, I found myself unstable and prone to falls in particular. Falls were often accompanied by great pain, bruising, swelling, and at least three days recovery time for pain to dissipate.

Also, my knee joint was wobbly, and it would go out of alignment and even just give way (usually causing a fall). Sometimes, it would just pop out of place while walking or standing. This necessitated adjustments to get it back “in place.”

Staircases were a particular challenge since I never knew when the knee would give way. Handrails narrowly saved me from falling several times. I was especially grateful for handicapped ramps, which I used to avoid stairs whenever possible. (I also thank the DMV for a six-month temporary handicapped placard.)

I had never experienced major injuries as an adult. I was a successful distance runner in high school, as well as a collegiate race walker. I participated actively in martial arts followed by more than a decade of yoga. Now I could barely walk. It was unfathomable and strange. I felt for all individuals who couldn’t walk, the disabled, and for all incapacitated persons. There’s nothing like direct experience. My perspective on many things is changed forever. For the better, of course.

I ultimately decided in favor of surgery, as my doctor recommended.


For several days, while recovering from a bruising fall (due to my knee giving way), I finally took time to seriously consider my best options for a fast recovery after surgery. I listed all the things (supplements, practices, techniques) I would do to create the most rapid return to normal function, walking, and ultimately running.

For example, I would have acupuncture immediately after surgery. I would ask for the minimum anaesthetic possible and I would avoid painkillers. I would continue my nutritional supplement regimen (see below), but add extra supplements for joint health, more antioxidants, and anti-inflammatory nutrients. I would be diligent about doing my physical therapy. As always, I would continue to meditate daily, but I would add guided visualizations for healing the knee. I would eat an extremely pure diet with a focus on organic vegetables and raw foods, as well as high-quality proteins.

Most of all, I would take large doses of REJUVENATE!™. I remembered back to the intense period in 2005–2006 when we (at HPDI) first taste-tested various versions of original Rejuvenate!™ superfood. I always volunteered (and still volunteer) as the #1 “guinea pig” during product development. I started slowly, but eventually took 10, 15, and even 20 scoops daily! One scoop is about 12 grams (or two tablespoons). I basically swilled this stuff all day. I ate, drank, breathed, and dreamed Rejuvenate!™ for months. I loved it!

I recalled how dramatically my energy levels increased when I took large doses (at least 8–10 scoops or more) of REJUVENATE!™. In addition, I had healed faster, gained greater muscle mass and functional strength, and had noticeably better lung capacity. I also lost some weight. Most intriguingly, I actually grew a little bit (in my early 40s no less!). It was a time of great discovery, intellectual ferment, as well as dark green Rejuvenate!™ lips and “mustaches” (“Got Greens?” we joked). Since then, I always take at least one or two scoops daily.

After the initial testing period for original Rejuvenate!™, I eventually stopped extremely large doses of it. This was partly because I discovered I gained most of the benefits at smaller doses. In fact, I benefit even from one or two scoops daily. Besides, I had started taking a few scoops daily of our newer Rejuvenate!™ formulas (i.e,. Rejuvenate!™ PRO, Rejuvenate!™ PLUS, Rejuvenate!™ Berries & Herbs, or  Rejuvenate!™ Strawberry-Peach Protein Plus), so I felt I was getting more than enough RNA from the combination of superfoods.

But now, everything had changed. Surgery would tax my body unlike anything else in my experience. I was already feeling quite taxed because my knee pain was virtually constant due to weekly falls. Even the original swelling from the accident had yet to resolve.

As I lay there in pain, reflecting upon my early experiences with large doses of original Rejuvenate!™, I realized I needed large doses of RNA for healing, both now and after surgery. It became clear to me that Rejuvenate!™ original would be the best single formula that could ensure a speedy recovery. I would take large doses of it.

I had good reasons for my decision to take large doses. First, original Rejuvenate!™ provides as much therapeutic dietary RNA as any other Rejuvenate!™ superfood. Dietary RNA (or nucleic acids) are the “secret” behind the healing power of the Rejuvenate!™ line, and indeed they remain the first and only dedicated high-RNA superfoods to this day.

Dietary RNA speeds (some say quadruples) healing time, increases cellular energy (as ATP) needed to improve cell functioning and optimize metabolic processes, boosts oxygenation, increases strength and endurance, and much more (see benefits list for RNA for Rejuvenate!™).

Rejuvenate!™ original provides about 340 mg of RNA (dietary nucleic acids) per serving. This is approximately the same amount of RNA per serving as all Rejuvenate!™ formulas provide (see Rejuvenate!™ comparison table).

Secondly, original Rejuvenate!™ remains our “greenest” superfood formula—providing the most chlorella, spirulina, and chlorophyll—in the Rejuvenate!™ line. The presence of these greens make it the most effective “healer” (gram for gram), at least for major trauma. Unlike some other Rejuvenate formulas (i.e., the PLUS and Berries & Herbs formulas), the original does not provide multivitamins, or even B vitamins (as Rejuvenate!™ PRO does).


Another major advantage is cost. Rejuvenate!™ original is the most highly concentrated source of RNA and other nutrients (e.g., chlorella and chlorophyll) in the Rejuvenate!™ line. Therefore, serving sizes are smaller (12 grams) and there are more servings per container. In fact, there are 42 servings (i.e., scoops) per container, which gives it the lowest cost per serving among all Rejuvenate!™ formulas.

My primary concern was never cost, of course, but effectiveness. Turns out the same concentration of nucleic acids (i.e., RNA density) that makes Rejuvenate!™ economically viable also allows it to provide the most healing RNA per gram.

Thus, given that the cost of original Rejuvenate!™ compares favorably to other Rejuvenate!™ formulas (some of which provide 16 servings per container), it is clear from a cost-benefit basis that original Rejuvenate!™ provides the greatest “bang-for-the-buck”and the biggest “bang-per-gram,” at least in terms of dosages of RNA and other dietary nucleic acids.

A healthy person (i.e., someone not experiencing trauma) can take a maintenance dose of one scoop daily for six weeks from a single container of Rejuvenate!™. When taking two scoops daily, a container lasts three weeks. Either way, this person would obtain therapeutic levels of RNA, despite relatively “small” servings of Rejuvenate!™.

For someone experiencing trauma or needing to heal, a relatively “large” dose of five scoops daily could still be provided by one container for more than eight days! (Compared to the cost of pharmaceuticals that do little or nothing to heal someone, the cost of Rejuvenate!™ starts to look like a real bargain.)

To be fair, the newer Rejuvenates offer significant additional features (e.g., built-in multivitamins, minerals, healing herbs) providing major benefits (especially when combined with RNA) that go well beyond the scope of original Rejuvenate!™. Yet, if you already take multivitamins and other supplements separately (as I usually do), and your primary interest lies in maximizing RNA intake, then original Rejuvenate!™ is by far the best choice.

In sum, original Rejuvenate!™ is especially appropriate when large amounts of RNA are required for healing, i.e., during times of injury, accidents, surgery and other medical interventions, trauma or critical conditions, and even for detoxification (heavy metals or chemical toxins).


I did not feel hungry for months following the accident. My lack of appetite extended for at least six months after the accident and then continued after the surgery. I suppose the trauma from the accident took away all desire to eat. Yet, I needed calories. I rapidly lost ten pounds shortly after the accident. Rejuvenate!™ original was tasty, easy-to-consume, and provided nutrients. It would make all the difference in my recovery.

For practical purposes, I already was living on Rejuvenate!™ superfoods months before surgery. It started long before I decided to take large doses of original Rejuvenate!™. While I forced myself to have a solid breakfast, most of the day I lived on Rejuvenate!™ original, and to a lesser extent Rejuvenate!™ PRO, and PLUS. I would mix them into smoothies, or shake them into rice milk or filtered water.

Prior to my decision to take large doses of Rejuvenate!™ original, I probably took a total of five scoops daily of various Rejuvenates combined. This was a good baseline. It provided reasonably large amounts of RNA and helped me to heal faster than I would otherwise. It also “preloaded” my body with RNA, so it was no shock to my body when I started taking large doses of Rejuvenate!™ original.

Then about six weeks before surgery, I ramped it up. I began taking 8–10 scoops of REJUVENATE!™ superfood (original greens) daily. I typically would take 2–3 scoops per dose, so I consumed three or four doses per day.

One of my favorite drinks was a Rejuvenate!™ “lemonade” made with freshly squeezed lemon or lime juice. I would add two scoops of Rejuvenate!™ to a mason jar, add pure water, the juice of one or two lemons, and possibly a dash of grade-B organic maple syrup. (If no fresh lemons or limes were available, I would often use a splash of Santa Cruz brand organic 100% lemon or lime juice.)

As mentioned, I would often also take up to four scoops per day of REJUVENATE!™ PRO or a few scoops of REJUVENATE!™ PLUS or REJUVENATE!™  Berries & Herbs. But mostly I focused on taking Rejuvenate!™ original.

I also continued my routine of taking a high-potency multivitamin, Vitamin C, essential fats, and a wide variety of antioxidants. Other supplements in my routine included a B-Complex, vitamin E, vitamin A, CLA, astaxanthin, magnesium, MSM, and a joint health formula.

I was also fortunate (and grateful) to receive regular acupuncture treatments from my wife, Stefanie, who is a professional acupuncturist with a master’s degree in oriental medicine. She treated me after the accident and immediately after surgery. Her treatments made a tremendous difference in reducing pain and swelling, and ultimately contributed greatly to my healing.


The day for surgery finally arrived. I decided to meditate as the anesthetic overcame me. I probably meditated throughout surgery. The first words I heard as I began to awaken were, “Are you meditating?” Still semi-conscious, I nodded to the nurse, who was pleased to get a rapid response. I left the surgery center that afternoon.

Recovery went smoothly and rapidly. First, the pain of surgery subsided quickly. Then, within the first week, I started walking again with the aid of crutches. In less than ten days, I walked without crutches.

My physical therapist was surprised to see that within two weeks I could extend out my leg while in a seated position almost to zero degrees. He said he almost never saw individuals with ACL injuries who extend so far in such a short period of time. In some cases, it takes months, he said.

In addition, I could now bend my knee nearly at 90 degrees. This meant the swelling from surgery was decreasing far more quickly than commonly occurs. In fact, I could feel and see the swelling decrease daily. I was healing many times faster than I would have otherwise. I attribute this to my action plan, including superior nutrition, and especially to Rejuvenate!™.

Another benefit I’ve always gained from Rejuvenate!™ is increased flexibility in the joints. However, I gain the most benefit at higher dosages, and this increased flexibility was evident during my post-surgical recovery.

Thus, higher doses of Rejuvenate!™ before (and after) my surgery 1) speeded healing, 2) increased strength, 3) improved joint flexibility, and 4) improved cellular oxygenation. These are the precise benefits that explain my ability to bend, lift, exhibit remarkable endurance, and heal rapidly during physical therapy.

Perhaps most surprising to my physical therapist was that I could raise my leg without any “extensor lag” (i.e., delay) on the very first day of physical therapy (i.e., one week after surgery). That is, I could easily lift my leg into the air from a seated (or lying down) position. According to the ACL graft instructions from my surgeon, this would normally be possible only three to four weeks AFTER surgery. My physical therapist recommended an accelerated rehabilitation program. I agreed enthusiastically.

My knee and leg felt stronger each passing day. I removed my brace for extended periods starting the third week after surgery. Before the end of the third week, I could extend my leg out fully to zero degrees. As the week flew by, I began sharing my action plan with my physical therapist. I told him about Rejuvenate!™, my supplement regimen, and benefits of acupuncture. He listened avidly.

During the third week after surgery, I could almost walk with a normal gait. I could also do full rotations on a stationary bike. Within the next few weeks, I could bike for many minutes and go for increasingly longer periods on stairstep-type machine. Thereafter, I began to return to normal activities, including walking greater distances and hiking. I would not attempt to run for a while. But sometime in the third month after surgery I recall my first running steps. It was thrilling to run.

I suppose I should be more amazed by the fact I healed so quickly and gained strength so fast. What surprised me was that I gained functional strength BEFORE surgery. That is, I noticed it was easier lifting objects and my grip strength was stronger within just days of increasing intake of Rejuvenate!™ to 10 scoops per day. That meant improvements in functional strength were due simply to increased dosages. Indeed, to me these improvements were solid indicators that additional energy would be available for accelerated healing and recovery, which was exactly what happened.

Thus, my “surprise” at the benefits of Rejuvenate!™ came before surgery. My enhanced experience with physical therapy was of course very welcome, but less surprising. By then, I just wanted to heal rapidly, then get back to normal life. Rejuvenate!™ helped make it happen!

In sum, the benefits I gained from Rejuvenate!™ included faster healing and recovery, increased strength, greater flexibility, improved oxygenation (i.e., better breathing) for greater endurance and less exertion, less pain (due to faster healing), and maintenance (i.e., less wasting-away) of muscle mass during recovery.

Another major benefit was higher caloric intake due to the ease of consuming Rejuvenate!™. This was especially important because I was hardly hungry for weeks after surgery with little desire to eat anything. Yet, I found it easy to make and take Rejuvenate!™ drinks. They are always tasty and go down easily.


I am happy to be healed! I have much gratitude for the ability to walk, and just to be alive. I’ve learned many things on the path to recovery. I would never wish to have an ACL tear (or any injury for that matter!) again. But I’ve gained perspective. I think in radically different ways since the accident. For example, I don’t take small things (or even big things like walking) for granted.

I still take 8–10 scoops of Rejuvenate!™ on most days. I was so greatly impressed with the extra benefits gained at a higher dosage of Rejuvenate!™ (original) that I continued high-dose intake after my recover. As a result, I continue benefiting from long-term improvements in functional strength, maintenance of high levels of lean muscle mass, greater endurance, easier breathing (via increased tissue oxygenation), high flexibility, tolerance of temperature extremes (heat and cold), as well as better athletic performance in all respects. Other benefits include smoother skin and a younger looking appearance (i.e., well known, proven results of increased intake of dietary nucleic acids (RNA, DNA) that are always welcome).

I highly recommend high dose Rejuvenate!™ to anyone suffering from major injury, chronic illness, or an intractable health problem. I also recommend it to anyone who is serious about detoxification (e.g., of heavy metals or toxic chemicals) or preventing toxicity, and to individuals desiring to improve athletic performance significantly. This latter group includes people who work physically for a living, and who can benefit from greater functional strength and endurance. I have seen many laborers who benefit from taking just one or two scoops a day. Benefits include less hunger, ability to work for efficiently and for longer periods of time.

I also recommend Rejuvenate!™ to those who must look good for a living. This group includes actors, models, public figures, health professionals, and almost anyone who would benefit from appearing younger and in radiant good health. (And who wouldn’t benefit from that?) The deeper truth here is that you will feel as good as you look because the health Rejuvenate!™ helps generate is not just “skin deep.” Instead, it is a reflection of actual good health from the inside out!

In conclusion, taking what I maybe used to think of as “large” doses Rejuvenate!™ is not just for special occasions. I think it can actually be for everyone, or at least most people. As life gets busier, as we get older, and as our environment becomes increasingly toxic (even as our personal environments and diets become less toxic, hopefully), it is clear that we not only need higher density nutrition, but also superfoods that can provide a wide range of benefits (e.g., detoxification, anti-aging effects, antioxidant capabilities).

The Rejuvenate!™ line of superfoods offers just these kinds of advantages. In particular, Rejuvenate!™ (original) offers unique benefits within the Rejuvenate!™ line that can benefit everyone from children to grandparents, athletes to recovery-room patients, and even pets.

There is every reason to believe that superfoods like Rejuvenate!™ are the foods of the future. They are available now, however. There is no reason to wait until an accident, an injury, or a decline in health generates a special need for super nutrition. You (and yours) can benefit starting now.

A superfood I already took at reasonable levels has become, by taking more of it, a superfood giving me optimal health every day. I maximize its effects. I gain all the benefits of peak levels of dietary nucleic acids, which are truly miracle nutrients.

I had never considered the long-term benefits of a dose increase. Now, I will never wonder what benefits I might lose since high-dose Rejuvenate!™ has become an integral part of my life.

The most important thing is you can benefit from Rejuvenate!™ high-RNA superfoods whether or not you take high dosages. However, it is also true that the nutritional power of Rejuvenate!™ is so great you can depend on “dose-dependent” benefits. That is, everyone benefits from even surprisingly small doses. Yet, if certain situations, conditions, or special needs exist, then they will respond positively to high dosages in ways that surpass normal dosage levels. This is the “next level” in terms of benefits and it represents optimal dosing for health.


Suggested Reading

Frank, Benjamin S., MD. Nucleic Acid Nutrition and Therapy. New York: Rainstone Publlishing, 1977.

Frank, Benjamin S., MD. Dr. Frank’s No-Aging Diet. New York: Dial Press, 1977.

Health Products Distributors, Inc. (HPDI). “The Master Rejuvenation Program. (http://www.integratedhealth.com/rejuvenation/index.html). c. 2010.

Health Products Distributors, Inc. (HPDI). “Rejuvenate Side-by-Side Comparison.” (http://www.integratedhealth.com/rejuvenate-comparison.html). c. 2010.

Jensen, Bernard. Chlorella: Jewel of the Far East. Escondido, California: Bernard Jensen International, 1992.

Liers, Henry, PhD, and Fred Liers, PhD. The Need for Foundational Supplements (http://www.integratedhealth.com/downloads/foundational-supplements.pdf). Tucson, Arizona: Health Products Distributors, Inc., 2010.

Pauling, Linus. How to Live Longer and Feel Better. Corvallis, Oregon: Oregon State University Press, 2006.


More Good News about Olive Oil

I love good olive oil! My recent studies into polyphenols and Nrf2 activators have made me more aware than ever of the importance of eating foods that retain the goodness that nature has packaged into foods. So more than ever I search for olive oils that are truly natural.

Recently, I learned that my friend Raymond has produced for him an olive oil that bypasses nutritionally all other olive oils of which I am aware. Raymond has sought out small family-owned farms in California, where the oil is literally produced in ways similar to methods used in ancient Greece and Rome.

Beyond Health Olive Oil

One of the best olive oils I’ve ever found

On these farms, olives are grown without pesticides and picked by hand so as to not damage the skin or pulp. They are transported in well-aerated containers and milled

within 48 hours of harvesting. Before milling, leaves and twigs are removed; the olives are washed, dried, and then crushed. The oil is separated from the olive paste without the use of heat, hot water, or solvents, and it is left unfiltered, as filtering also removes many nutrients.

The first pressing produces the best extra virgin oil. Producing olive oil the old way is more time consuming and costly. The costs of harvesting by hand, to protect the fruit from damage, are high, but necessary to making good oil.

We will soon sell this extra virgin olive oil on the Health Products Distributors, Inc. website. This makes me happy! I always want to make the most health giving foods and nutrients available to our customers.

Interesting, today there was an article on the benefits of olive oil posted on the Natural News website that talks about a recent study published in the American Journal of Clinical Nutrition. The conclusions reached after studying 40,622 participants in a 13.4 year study is that olive oil consumption lowers mortality by a quarter and heart disease by nearly one-half!! Incredible!!!

Digase™ (Digestive Enzyme Design Rationale) Part 2: the Formula

In Part 2 of the Product Rationale for our Digase™ enzyme formula, we present  both its various components and the functions each performs in the product.

You may also wish to read Part 1 of the Product Rationale.


The enzymes and herbs contained in the latest, improved Digase™ formula are shown below:

Amylase 2,500 DU *
Glucoamylase 9 AGU *
Invertase (Sucrase) 200 SU *
Maltase Diastase 500 DPo *
Protease 4.5 8,000 HUT *
Peptidase FP 2,000 HUT *
Protease 6.0 4,000 HUT *
CereCalase™ 7.5 mg *
Protease 3.0 (acid stable) 8 SAPU *
Alpha-Galactosidase 60 GALU *
Lipase 250 FIP *
Cellulase 200 CU *
Lactase 250 ALU *
Caraway Seed (Carum carvi) 70 mg *
Gentian (Gentiana lutea) 70 mg *
Ginger Rhizome (Zingiber officinale) 70 mg *

* No established Daily Value
† Enzyme activity specified according to standard FDA accepted Food Chemical Codex procedures


Amylase, Glucoamylase, Malt Distase, Lactase, Invertase, Alpha-Galactosidase, Cellulase and Cerecalase™

Starch is abundant in the natural world where it serves as the primary energy source for plants, animals and humans. Starch consists of glucose polymers. These polymers exist in two basic compositions, amylose and amylopectin. Amylose, the minor constituent, consists of straight chains of glucose joined with alpha-1,4-glucosidic bonds. Amylopectin consists of branched glucose chains. The branching of the glucose chain occurs with the formation of an alpha-1,6-glucosidic bond. The ratio of amylose to amylopectin varies dependent upon the origin of the starch but is typically in the range of 1:3 to 1:4.

Starch digestion is optimized with the combination of the enzymes alpha-amylase, glucoamylase and malt diastase. While alpha-amylase breaks glucose-glucose bonds at random points within the starch chain, malt diastase hydrolyzes the starch chain from the ends to create glucose dimers (maltose) and glucoamylase breaks single glucose molecules off the ends of the chain. The hydrolytic action of both alpha-amylase and malt diastase is blocked by the alpha-1,6-glucosidic bonds of amylopectin.

The conformation of these limit dextrins prevents the active site of the enzymes from coming in contact with the glucose-glucose bonds thus inhibiting hydrolysis. Glucoamylase hydrolyzes the alpha-1,6-glucosidic bond, freeing the chain for continued hydrolysis of the alpha-1,4-bonds. The action of these three enzymes are outlined in the following three figures which clearly show the benefit of combining amylase, malt diastase and glucoamylase for the liberation of glucose.


FIGURE 1. Action of Amylase (/) without the presence of Glucoamylase for the hydrolysis of amylopectin (component of starch).



FIGURE 2. Action of Amylase and Malt Diastase (/) without the presence of Glucoamylase for the hydrolysis of amylopectin (component of starch). Spaces represent sites of Amylase action.



FIGURE 3. Action of Amylase, Malt Diastase and Glucoamylase (/) for the hydrolysis of amylopectin (component of starch). Spaces represent sites of Amylase and Malt Diastase action. Glu (underlined) represents molecules of free glucose available after hydrolysis is complete.


The ratio of amylase and glucoamylase activities is relatively standardized with the data for the development of the ratios being derived from the sugar industry.

The amount of lactase in the product is low in comparison to the original Lactaid® formulation. Individuals who do not have dairy problems are not paying for an expensive enzyme with little direct benefit to them. However, those who are lactose intolerant can increase their dosage with dairy consumption to help prevent their symptoms. In comparison to most other products on the market positioned as general digestive supplements, the proposed product is similar in lactase activity.

In regards to alpha-galactosidase, this enzyme is characterized by its ability to hydrolyze the alpha-1-6 linkages in melibiose, raffinose, and stachyose, sugars commonly found in vegetables especially of the legume and cruciferous families. Taken as a supplement, alpha-galactosidase decreases the incidence of flatulence associated with the consumption of raffinose-containing vegetables. The level of invertase in Digase™ is comparable to other general digestive products.

Cellulase and CereCalase™ enzymes offer distinct advantages for individuals consuming large amounts of grains, beans and other vegetable feedstuffs. These enzymes hydrolyze the bonds in various fibers. Cellulase hydrolyzes glucose-glucose bonds in cellulose. By disrupting the structure of the fiber matrices which envelop most of the nutrients in plants, cellulase increases the nutritional value of fruits and vegetables.

CereCalase™ is a proprietary blend of three enzymes—hemicellulase, beta-glucanase and phytase—that work together to macerate, or disrupt, the cell walls of fruits, vegetables, seeds and herbs. These three enzymes hydrolyze non-starch polysaccharides (NSPs) which can have anti-nutritive effects. NSPs have also been shown to bind digestive enzymes and inhibit mineral absorption.


The complexity of proteins and peptides requires the combination of multiple proteases to optimize digestion. Proteins are made up of over twenty different amino acids with each combination presenting different conformational characteristics. Each proteolytic enzyme has different bond specificities and thus a combination shows the greatest rate of hydrolysis. Bond specificity is an ongoing area of research in enzymology. However little has been done on the various Aspergillus proteases.

Peptidase breaks amino acids off the ends of the peptide chain. Our supplier’s (National Enzyme Company (NEC)) peptidase possesses both amino-peptidase and carboxy-peptidase activities and thereby can remove amino acids from both ends of the peptide chain. Protease 4.5 and Protease 3.0 break at points within the peptide chain dependent upon their bond specificities. While these specificities have not been fully elucidated, significant differences in the action of these enzymes have been seen both in the laboratory and in digestive product usage.

The pH optima and ranges of these two enzymes is also an important benefit of combining these proteases. Protease 4.5 has an optimal pH of 4.5 (pH range 2.0 to 6.0) while Protease 3.0’s optimum is pH 3.0 (pH range 2.0 to 7.0) and Protease 6.0 has an optimal pH of 6.0 (pH range 4.0 to 11.0). Together these proteases provide proteolytic action throughout the human digestive system.


The lipase included in Digase™ has a very broad range activity and is capable of hydrolyzing all three triglyceryl bonds yielding free fatty acids and glycerol. Many lipases hydrolyze only the 1- and 3-positions. In contrast, the Aspergillus niger lipase is capable of breaking the bonds at all three positions although the 2-position is hydrolyzed at a slightly slower rate.

In addition, our lipase shows an optimum pH of 5.0 with an active range of pH 3.0 to 9.0. The LU level for this formulation is in the middle to high range of modern digestive formulations and is comparable with the level used in current research.

Gentian Root (Gentiana lutea), Ginger Rhizome (Zingiber officinale), and Caraway Seed (Carum carvi)

Three herbs have been incorporated into this formula to support the digestive action of the food enzymes. Gentian Root (Gentiana lutea) is a bitter herb which is recognized worldwide as one of the most effective gastric stimulants. This herb is widely used to improve digestion and stimulate appetite as well as being beneficial for all types of gastrointestinal disorders including dyspepsia, gastritis, heartburn, and nausea. Research shows that the bitter principles found in Gentian stimulate gastric secretions and have choleretic activity; substantiating the herbs effectiveness for digestion.

Ginger Rhizome (Zingiber officinale) is an incredibly active and effective gastrointestinal aid with the following properties: 1) Contains a digestive enzyme whose effectiveness even exceeds that of papain, 2) Stimulates the flow of saliva and increases dramatically the concentration of the digestive enzyme amylase in the saliva, and 3) Activates peristalsis and increases intestinal muscle tone.

Caraway Seed (Carum carvi) further supports healthy digestion. This herb has carminative and antispasmodic activities that help to soothe the stomach and ease digestion. Caraway also benefits this formulation by its action to increase digestion of fats. Like Gentian Root, Caraway Seed has also been shown to stimulate the appetite.


Due to the catalytic nature of enzymes, any amount (no matter how small) will increase the rate of reaction. Larger potencies simply serve to increase the rate to a higher level, at least within the kinetic ability of the enzyme. Since these enzymes are safe and non-toxic, high activity levels are more cost- and marketing-driven than scientifically established. A game of “our potencies are higher than theirs” is currently one of the most common marketing ploys.

The area of greatest concern in enzyme formulation is in achieving the proper balance in the enzyme ratios. Broadening the formulation to contain multiple proteases and carbohydrases is a valid way to improve the activity of any product. The benefits relate to the specificity of each enzyme. Since each enzyme catalyzes reactions at different sites, multiple enzymes can quickly increases the rate of hydrolysis and improve the bioavailability of amino acids, sugars and fatty acids.



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Bradley, P.R., ed. British Herbal Compendium, Volume 1, (Dorset, England: British Herbal Medicine Association, 1992).

Cichoke, Anthony J., Enzymes & Enzyme Therapy: How to Jump Start Your Way to Lifelong Good Health, (New Canaan, CT, Keats Publishing, 1994).

Duke, J.A., Handbook of Medicinal Plants, (Boca Raton, FL: CRC Press Inc., 1985).

Ghose,T.K. and Pathak, A.N. “Cellulase-2: Applications” Process Biochemistry, 20-24, May 1973.

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Lennard-Jones, J.E. “Functional gastrointestinal disorders.” New England Journal of Medicine 308: 431 (1983).

Murray, R.D., et. al. “Comparative absorption of [13C] glucose and [13C] lactose by premature infants,” American Journal of Clinical Nutrition 51: 59-66 (1990).

O’Keefe, S.J.D., et. al. “Milk-induced malabsorption in malnourished African patients,” American Journal of Clinical Nutrition 54: 130-135 (1991).

Prochaska, L.J.; Piekutowski, W.V. “On the synergistic effects of enzymes in food with enzymes in the human body. A literature survey and analytical report.” Medical Hypotheses 42: 355-62 (1994).

Schwimmer, S., Source Book of Food Enzymology, (Westport CT, The AVI Publishing Company, Inc., 1981).

Thacker, P.A.; Campbell, G.L.; GrootWassink, J. “The effect of enzyme supplementation on the nutritive value of rye-based diets for swine.” Canadian Journal of Animal Science 71: 489-96 (1991).

Theiss, B. and Theiss, P., The Family Herbal, (Rochester, VT: Healing Arts Press), 1989).

Weiss, R.F., Herbal Medicine, (Gothemburg, Sweden: AB Arcanum, 1988).




The following table provides details of the “typical” meal around which the Digase™ formula was designed. Two capsules of the formula provide as much as 80% of the digestive power needed to digest this 1000 kilocalorie, high-fat meal.


Animal Protein 12% 50 grams
Vegetable Protein 8% 20 grams
Animal Fat 17.5% 19.5 grams
Vegetable Fat 17.5% 19.5 grams
Carbohydrate 45% 112.5 grams
Fiber (non-digestible) 10 grams





Amylase Aspergillus oryzae ferment
Protease 4.5 Aspergillus oryzae ferment
Protease 6.0 Aspergillus oryzae ferment
Protease 3.0 Aspergillus oryzae ferment
Peptidase FP Aspergillus oryzae ferment
Invertase Saccharomyces cerevisiae
Malt Diastase Hordeum vulgare malt
Lactase Aspergillus oryzae ferment
Cellulase Trichoderma long brachiatum
Lipase 21179 Aspergillus niger ferment
Alpha-Galactosidase Aspergillus niger ferment
CereCalase™ Aspergillus niger ferment

Gardening for Super Health

Hank's GardenI love to grow vegetables in my backyard and have been doing so on-and-off for 50 years now. It’s such a pleasure to prepare the soil, plant the seeds/seedlings, tend them as they grow, and finally enjoy the harvest. My thumb is relatively green, so harvests have been plentiful and tasty. Possibly, something rubbed off from watching my father do his gardening. He was a very serious gardener and fed his family from the garden during WWII.

However, during the last 25 years my interest in gardening grew much more focused. As I became a designer of nutritional supplements and had to nourish my wife who had become chemically sensitive, I was keenly aware that the foods and supplements we consume are of the upmost importance.

Due to her chemical sensitivities since 1985, for example, my wife finds it necessary to eat only organically grown foods. The penalty she pays for eating any non-organic foods from the supermarket are severe joint pains all over her body! For years, I travelled 120 miles every Saturday to purchase a week’s supply of organic fruits and vegetables.

I read incessantly to understand how to be truly healthy — and because I was now house chef — how to prepare truly healthy meals. I learned about a place called Findhorn in Scotland where a group of people were growing astoundingly healthy and huge vegetables using special growing methods that I recall included something called “rock dust.”

I later learned from Rutgers University’s Firman E. Baer Report that differences in mineral content in plants grown in “good soil” versus plants grown in “poor soil” are often enormous. That is, plants grown in “good soil” can be 100 times (or more) richer in certain minerals!

After we moved to Southern Arizona in 1993, I heard from a friend about worm beds and castings and started a worm bed in our yard. Shortly thereafter, I purchased a 50 pound bag of rock dust and started using it along with a product called EM (“Effective Microorganisms”) that enhanced the soil with beneficial microorganisms. Our neighbors and gardener found it hard to believe the plants we grew were so healthy and productive! We continued enhancing the soil and enjoyed a highly productive garden for years.

Then in 2009, I built several very large raised beds so that I could control the soil more completely and purchased a 50 pound bag of rock dust (Agrowinn Minerals) from a company in Southern California (www.fertilizeronline.com). Using this rock dust along with plenty of compost I grew amazingly large and healthy vegetables such as zucchini, squash, tomatoes, eggplant, peppers, parsley, etc. I used these vegetables daily in preparing salads, stir fries, soups, and other dishes.

My wife felt so good eating these garden-fresh (and mineral-rich) dishes, she thereafter refused to eat anything except meals prepared from garden produce! Now, something in my head started to churn! Our high quality garden foods make an enormous difference to the person eating them. Everything I’d read and heard about trace minerals is true: our health depends upon it!

In 2011, I hired a new employee (Linda Leigh) who runs a side business (Vermillion Wormery) raising red wiggler worms. I learned from her how to use worm castings tea (and I built another worm bed that effectively recycles all of my organic kitchen wastes). When done correctly, vermicompost tea produces a huge number of aerobic microorganisms that take up nutrients from the soil (including rock dust), and then convert them into organic forms readily available to garden plants.

More recently, I learned that in the aftermath of the Chernobyl nuclear disaster in the Ukraine, dairy cows consuming grass fertilized with rock dust had no radiation in their milk. Yet, cows just down the road eating grass not fertilized with rock dust had radiation in their milk! This indicates when you are replete with the proper amount of trace minerals your body needs, you will NOT absorb minerals of a similar nature that are radioactive (e.g., cesium-137 and strontium-90)!

In these times, when our health is adversely affected by a broad range of environmental, nutritional, and lifestyle factors, it’s important to know you can easily grow your own super healthy foods, especially using the methods I describe (above). Growing your own organic and biodynamic foods is a major step towards creating super health for yourself, as well as for your family, friends, and pets.

As it turns out (not unexpectedly!), another benefit of gardening and farming is better immunity and health through exposure to soil microorganisms. Thus, it appears that in addition to the benefits of eating mineral-rich garden produce, simple exposure to soil microorganisms in “a little dirt” while gardening is itself a very good thing for health! For more information on this subject see our blog article entitled “A New View of the Role of Bacteria in Health“.


Note: you may also enjoy my related blog post (from June 14, 2012): Living with Radiation: Protection Starts Today. That post deals with specific measures (diet, supplements, etc.) you can use to protect yourself from radiation.


The best place to buy rock dust and worm castings in the USA:

Here is a place in Scotland that tells their story about rock dust:

This website is all about remineralization of the earth. Highly recommended!

Here is an excellent website on worm castings, including worm castings tea:

New York Times article on health benefits of exposure to soil microorganisms:

For those interested in the details of soil biology, here is an online book on the subject:



Digase™ (Digestive Enzyme Design Rationale) Part 1: the Need for Supplementation

Here we present our Design Rationale for Digase™, Health Products Distributors, Inc.’s plant-based enzyme supplement formula. This Design Rationale includes product background information and a discussion of the need for individuals to supplement diet with digestive enzymes to create, support, and maintain optimal health.

Digase™ remains among our most popular digestive enzyme formulas. It is an effective, plant-based enzyme supplement providing a full spectrum of digestive enzymes plus digestion stimulating herbs.

Digase™ provides proteases (optimized for pHs of 3.0, 4.5, and 6.0), peptidase, lipase, and carbohydrases, including amylase, glucoamylase, invertase (sucrase), maltase, alpha-galactosidase, lactase, phytase, cellulase, and hemicellulase.

CereCalase™ is included to break down phytic acid, a substance that can prevent proper absorbtion of minerals in the diet.

Digase™ includes three digestion-stimulating herbs: ginger root, gentian root, and caraway seed.

Dr. Hank Liers designed Digase™ to be the most effective plant-based supplement available. Applying his understanding of digestive enzymes’ modes of action to bear on the development and design of Digase™, HPDI believes this product to be among the most advanced enzyme formulas on the market today.



The digestive system prepares food for use by the body’s cells. If food is not digested, it cannot reach the cells and is not in the appropriate form or chemical state. The digestive system modifies food physically and chemically through the use of exocrine and endocrine secretions as well as through the controlled movement of food through the digestive tract.

Digestion begins when food first enters the mouth. Here the first mechanical process occurs with the act of chewing. In addition, the body’s first enzymes are added to the food with saliva. This enzyme is called ptyalin and consists of amylolytic enzymes. As the food travels down the esophagus via peristaltic action, ptyalin as well as any endogenous enzymes continue the digestive process started in the mouth.

After the food bolus has entered the stomach, it may remain in the fundus or upper region of the stomach for as long as an hour until the food is mixed with the stomach secretions.During this time salivary amylase and food enzymes continue digestion. Research has shown that salivary amylase can digest as much as 30 to 40% of the starches present before mixing occurs.

The stomach continues mechanical digestion through churning the bolus into a creamy chyme. Several enzymes (see Table 1) are secreted in the stomach including gastric lipase (tributyrase), gastric amylase, gelatinase and pepsinogen. Pepsinogen is the inactive form of the proteolytic enzyme pepsin which is activated via acid hydrolysis with the hydrochloric acid secreted by the stomach. Thus, the stomach begins the enzymatic digestion of protein and to a limited extent fats.

As the chyme moves into the duodenum, the pancreas is stimulated to produce additional digestive enzymes. Pancreatic secretions includes enzymes for the digestion of proteins, carbohydrates and fats. Secreted proteolytic enzymes include trypsin, chymotrypsin, carboxypolypeptidase, elastases and nuceleases. Proteolytic enzymes breakdown proteins into peptides of various sizes and free amino acids. Pancreatic amylase hydrolyzes starches, glycogen and other digestible carbohydrates into di- and trisaccharides.

Similar in action to salivary amylase, pancreatic amylase is several times more powerful and is the major agent in the digestion of starches and other complex carbohydrates. Fats are hydrolyzed by pancreatic lipase, cholesterol esterase and phospholipase. Together these lipolytic enzymes provide for the digestion of phospholipids, cholesterol and fats. To support fat digestion and absorption, bile is secreted by the liver. The bile salts function to aid emulsification of fat particles as well as transport and absorption of fatty acids, monoglycerides, cholesterol and other lipids through the intestinal mucous membrane.

Upon entrance to the small intestine, additional enzymes are present to further digest the ingested foods. Peptidases, disaccharidases, and intestinal lipase are located within the brush border cells where they complete digestion thus allowing absorption. Disaccharidase enzymes include sucrase, maltase, isomaltase, and lactase and function to hydrolyze disaccharides into monosaccharides. Absorption of nutrients takes place in the small intestine.

Having been digested into the appropriate form, monosaccharides, amino acids, fatty acids and other nutrients are absorbed across the intestinal mucosa and transported via the blood stream for use by cells throughout the body.

TABLE 1. Overview of Enzymes in the Healthy Human Digestive Tract
amylase starch maltose, dextrins
tributyrase butter fats free fatty acids, di-, monoglycerides
pepsin proteins peptides
gelatinase proteins peptides
amylase* starch, glycogen, COH maltose, dextrins
pancreatic lipase* fats (triglycerides) free fatty acids, monoglycerides
cholesterol esterase cholesterol esters free fatty acids, cholesterol
phospholipase phospholipids free fatty acids
trypsin* proteins/peptides peptides
chymotrypsin proteins/peptides peptides
carboxypolypeptidase peptides free amino acids
elastases proteins/peptides peptides
nucleases proteins/peptides peptides
small intestine
dipeptidases peptides tripeptides, dipeptides
aminopolypeptidase peptides tripeptides, dipeptides
peptidases tripeptides, dipeptides free amino acids
intestinal lipase tri-, diglycerides free fatty acids
sucrase sucrose glucose, fructose
maltase/isomaltase maltose glucose
lactase lactose glucose, galactose
dextrinase limit dextrins glucose
* enzymes responsible for the greatest percentage of digestion of carbohydrates, fats and proteins.




Under optimal conditions, it could be argued that the human body needs no supplementation of enzymes. As the table above indicates, the human body is quite capable of producing the enzymes necessary to digest food and allow for the absorption of nutrients. However, with estimates that as many as twenty million Americans suffer from various digestive disorders, optimal conditions are not the norm for most people.

In fact, digestive problems can cause improper digestion and malabsorption of nutrients with far reaching effects. Consequences of malabsorption may include impaired immunity, allergic reactions, poor wound healing, skin problems, mood swings, etc. Supplemental enzymes can improve the effectiveness of digestion and help assure maximum levels of nutrient absorption by the body.




All raw foods naturally contains the proper types and proportion of enzymes necessary to digest themselves (whether in human consumption or in the eventual decomposition in the natural world). When raw food is eaten, chewing ruptures the cell membranes and releases the indigenous food enzymes to begin the selective breakdown of substrates.

Proteases break long protein chains (polypeptides) into smaller amino acid chains and eventually into single amino acids. Amylase reduces large carbohydrates (starches and other polysaccharides) to disaccharides including sucrose, lactose, and maltose. Lipases digest fats (triglycerides) into free fatty acids and glycerol.

Cellulase and CereCalase™ (not found in the human system) break the bonds found in various fibers. By disrupting the structure of the fiber matrices which envelop most of the nutrients in plants, cellulase and CereCalase™ increase the nutritional value of fruits and vegetables.

Overwhelming evidence shows that food enzymes play an important role in digestion by predigesting food in the upper stomach before hydrochloric acid has even been secreted. Supplementation of food enzymes is necessary in today’s society due to the prevalence of cooked and/or processed foods.

Most food enzymes are essentially destroyed at the temperatures used to cook and process food leaving foods devoid of digestive enzyme activity. Placing the full digestive burden on the body, the body’s digestive process can become over-stressed and vital nutrients may not be released from food for assimilation by the body.

Unlike supplemental enzymes of animal origin, plant enzymes work at the pH found in the upper stomach. Food sits in the upper portion of the stomach for as long as an hour before gastric secretions begin action. Several studies conducted at major universities have shown that the enzymes in saliva continue their digestive activity in the upper stomach and can digest up to 30% of the ingested protein, 60% of ingested starch and 10% of ingested fat during the 30 to 60 minutes after consumption.

Although salivary enzymes accomplish a significant amount of digestion, their activity is limited to a pH level above 5.0. Exogenous plant enzymes are active in the pH range of 3.0 to 9.0 and can facilitate the utilization of a much larger amount of protein, carbohydrates and fat before HCl is secreted in sufficient amounts to neutralize their activity. Obviously, plant enzymes can play a significant role in improving food nutrient utilization.

In addition to protease, amylase, lipase, and cellulase, it is important to provide a concentrated source of the disaccharidases Lactase, Invertase and Malt Diastase. Disaccharide intolerance occurs when insufficient levels of disaccharidase enzymes are secreted in the small intestine causing malabsorption and physical discomfort. Lactase deficiency is the most common and well-known form of carbohydrate intolerance.

Lactase digests lactose (milk sugar) into glucose and galactose. Most mammals, including humans, have high intestinal lactase activity at birth. But, in some cases, this activity declines to low levels during childhood and remains low in adulthood. The low lactase levels cause maldigestion of milk and other foods containing lactose.

It is estimated that approximately 70% of the world’s population is deficient in intestinal lactase with more than one third of the US population presumed unable to digest dairy products. Supplemental lactase has been found to decrease the symptoms of lactose intolerance associated with consumption of dairy foods.

Invertase is another disaccharidase that works to break down sucrose (refined table sugar) into glucose and fructose. The prevalence of processed and highly refined foods in the Standard American Diet (SAD) means Americans consume a large amount of this sugar, which can contribute to excessive digestive stress. It is theorized that unrecognized sucrose intolerance is a contributing factor in many allergies. Supplemental Invertase can increase the assimilation and utilization of this sugar.

The additional supplementation of the carbohydrase Malt Diastase augments the breakdown of starch into glucose molecules, allowing greater absorption of this energy-giving sugar. Inclusion of these sugar-breaking enzymes gives Digase™ a broad base for improving nutrition.


Also see Part II of the Digase™ Design Rationale.


Other HPDI formulas supporting digestion and intestinal health:

Prolyt (proteolytic enzyme formula with bioflavonoids)
Polydophilus (probiotic formula plus fructooligosaccharides)
Intestinal Rejuvenation Formula (intestinal cleansing formula)