High-RNA Rejuvenate! Superfood

Dr. Hank Liers, PhDIn this article I will provide a bit of history and my excitement concerning the development of our high-RNA Rejuvenate! superfood. Over the past 25 years I have formulated hundreds of nutritional supplement products. As you may know, I first entered into the business of formulating and selling nutritional products because of my wife Joanne’s extreme multiple chemical sensitivities. The challenge to me always was to design products that even the most sensitive person could tolerate, and to create products that would provide significant benefit to individuals taking them.

I spent a great deal of my time reading scientific and clinical studies that showed the most effective forms and amounts of the ingredients. In addition, I read books on physiology, endocrinology, immunology, and biochemistry in order to understand how certain nutrients would be used in and affect the body. On occasions when I saw new possibilities for products with great potential I would take extra time with my research in order to ensure that I produced a groundbreaking product. This is the case with Rejuvenate!™.

Rejuvenate! High RNA Superfood rejuvenate


In 2004, I first learned about the benefits of ribonucleic acids (RNA) as nutritional supplements. Initially, I discovered the idea of consuming dietary nucleic acids from several books by Dr. Bernard Jensen that my son, Fred, was reading at the time. These books included Food Healing for Man (1983) and Chlorella: Jewel of the Far East (1992).

Dr. Jensen told the story of a man named Charlie Smith. According to Dr. Jensen, this man had received a honorary high school degree at the age of 133. When Dr. Jensen visited Charlie Smith, the oldest living American at the age of 135, he was healthy, clear-minded, and had a wonderful memory.

Dr. Jensen’s first question for Charlie was, “What have you been eating for the last 30 years?” Charlie’s reply was that he ate canned sardines and crackers. Dr. Jensen couldn’t believe it. But after some investigation, he found out that canned sardines were the highest-known food in RNA.

We soon discovered references in Dr. Jensen’s books to the works of Dr. Benjamin S. Frank. Among Dr. Frank’s writings is Dr. Frank’s No-Aging Diet (1976). As presented in his bestselling book, the main components of Dr. Frank’s diet are: 1) one three-to-four ounce can of sardines at least four days per week, and some fish including salmon and other seafood on the other days, 2) calf liver once per week, and 3) beans or lentils once or twice weekly.

Dr. Frank had done extensive research on both humans and animals using his diet. In his books, he recommends a diet high in nucleic acids to counter the aging process and essentially to rejuvenate the body. We were astonished at the health benefits (see list below) reported by Dr. Frank. Benefits he found not only include improved tissue oxygenation and cellular energy production, but also smoother skin and a more youthful appearance. It was an exciting time for us. We could hardly wait to try Dr. Frank’s “no-aging” diet for ourselves!














After learning about the many health benefits of dietary nucleic acids, my family immediately began consuming sardines on a daily basis. We felt and saw the difference! We noticed we had greater energy levels, breathed easier (especially noticeable when exercising), greater tolerance to cold temperatures, and even smoother skin. Even our dogs gained these benefits!

I was somewhat surprised at these noticeable effects on health since for many years we had already been consuming a healthy diet of organic foods, taking high-quality nutritional supplements, and getting plenty of exercise.

In another book written by Dr. Frank, Nucleic Acid Nutrition and Therapy (1977), he notably states that nucleic acids [RNA and DNA] are “essential nutrients of human beings,” as distinct from non-essential, accessory nutrients. He considered nucleic acids and nucleotides an essential dietary category, i.e., as being nutrients just as essential for humans as vitamins, minerals, proteins, carbohydrates, and lipids.

Dr. Frank acknowledged the body’s capacity to synthesize some nucleic acids, yet cited the marked improvements in degenerative conditions as the clearest evidence for nucleic acids as essential nutrients. In particular, he noted the health effects resulting from even relatively small intakes of nucleic acids (e.g., energizing effects, anti-anoxia effects, rejuvenation, greater vitality, etc). Dr. Frank found he could not obtain such improvements in his subjects by increasing only the intake of vitamins, minerals, proteins, or other essential nutrients.

Dr. Frank asserts: “Nucleic acids are an essential nutrient in our daily diets, and…optimal health and reduced aging are clearly related to their intake, more than to any other nutrient. Nucleic acids in our diets are of paramount importance for the repairing of molecular and gross tissue degeneration, and for combatting the process of aging by simple, effective and essentially non-toxic, natural means.”


I was absolutely impressed by the results we were observing, and by what Dr. Frank had discovered in his many experiments on humans and animals. But then things got more interesting! Because shortly thereafter, I read another book on chlorella by Dr. Jensen, Chlorella: Gem of the Orient (1987). Chlorella is single-cell freshwater algae with an RNA content in the range of 5–15%. Chlorella was being used extensively in Japan as a cure for virtually any illness.

My thoughts soon turned to developing a vegetable-based nutritional product that was a high-RNA superfood with nutrients that would support the body’s use of and production of  nucleic acids. Soon, I was reading every book written by Dr. Frank (a great challenge and learning experience in itself!) in order to gain a deeper understanding of what was required by the body in order to produce and utilize RNA. Piece by piece, the the elements of the formula fell into place. In January 2007, Rejuvenate!™ was ready. Here’s what Rejuvenate!™ contains:


  • Chlorella (Chlorella pyrenoidosa) . . . . . . . . .      5,000 mg
  • Nutritional Yeast (no added ingredients) . . . .      1,500 mg
  • D-Ribose . . . . . . . . . . . . . . . . . . . . . . . . . . . . .       1,500 mg
  • Chia Seeds (Organically Grown) . . . . . . . . . . .     1,000 mg
  • Rice Bran Solubles . . . . . . . . . . . . . . . . . . . . .        1,000 mg
  • Spirulina Pacifica® . . . . . . . . . . . . . . . . . . . .        1,000 mg
  • Magnesium Malate . . . . . . . . . . . . . . . . . . . . . .        300 mg
  • Magnesium Ascorbate . . . . . . . . . . . . . . . . . . . .       290 mg
  • Chlorella Growth Factor (CGF) . . . . . . . . . . . . . .     150 mg
  • Organic Dulse. . . . . . . . . . . . . . . . . . . . . . . . . .            75 mg
  • Organic Kelp . . . . . . . . . . . . . . . . . . . . . . . . . .             75 mg
  • Yeast Ribonucleic Acid (RNA) . . . . . . . . . . . . . . . .    40 mg
  • Calcium Folinate. . . . . . . . . . . . . . . . . . . . . . .         260 mcg
  • Methylcobalamin (Vitamin B12). . . . . . . . . . . . .   100 mcg

For an in-depth discussion of Rejuvenate! (original) please visit the HPDI website.

We have been extremely pleased with this product and the results gained by the individuals who consume Rejuvenate!™. Below are some of the testimonials we have received from satisfied customers.


“…My Skin Has Never Looked Better!”
– Stefanie L, Tucson, Arizona

“…a real energy booster! I’ve been surprised to feel increased vitality right away when drinking even a half dose!”
– Susanne L., Salisbury, Maryland

“I want to run a marathon! I wouldn’t be without this product for a day…”
– Karen W., Kirkcaldy, Scotland, UK

“I used to fight daily to not fall asleep in the afternoon, but now I have so much more energy…I go running in the afternoon even after surfing in the morning and waking up at 4:45 am!”

– Ariana H., Santa Cruz, California

“Best tasting green food I have tried out of many, congratulations!”

– Richard F., Virginia Beach, Virginia

“REJUVENATE! has been like a gift from God for my condition…thank you so much, more than words can ever say.”

– Jason W., Lake Arrowhead, California

“I am feeling better than I have in 30 years. (I am 63 years old.)…You can bet you have a repeat customer here. I will surely recommend this product to others.”
– D. Engel, Sibley, Iowa


After formulating Rejuvenate! (original greens), I created a complete line of high-RNA Rejuvenate! superfoods that provide a broad range of additional benefits. These include Rejuvenate! PLUS and Rejuvenate! Berries & Herbs.

Original Rejuvenate!™ remains our “greenest” superfood formula and contains the most chlorella per serving. Rejuvenate!™ PLUS is a lighter green, slightly sweet tasting superfood with an added multivitamin complex, and it provides the same total amount of dietary nucleic acids. Rejuvenate!™ Berries & Herbs offers an amazing berry taste, contains no greens, and not only provides the same amount of dietary nucleic acids, but also a built-in multivitamin complex and a cell-protecting herbal complex.

We know how effective Rejuvenate!™ superfoods are for total body rejuvenation, boosting health, supporting recovery and healing, boosting exercise performance, and improving personal appearance. We’d like you to experience these benefits, too.

Try any one of the Rejuvenate!™ superfoods for yourself, so you can start gaining all the benefits of dietary nucleic acids today! See our Rejuvenate!™ comparison page for more details about HPDI’s complete line of Rejuvenate! superfoods.

We also offer a pet version of Rejuvenate!™ known as Rejuvenate!™ For Pets. The ingredients in the pet Rejuvenate! formula are identical to the human version, but it comes packaged in a smaller container suitable for pets of all sizes and ideal for traveling.


  1. Chlorella: Jewel of Far East, Bernard Jensen, PhD, 1992.
  2. Chlorella: Gem of the Orient: The Dynamic Food Discovery for Health and Healing, Bernard Jensen, PhD, 1987.
  3. Dr. Frank’s No-Aging Diet, Dr. Benjamin Frank, 1976.
  4. Nucleic Acid Nutrition & Therapy, Benjamin S. Frank, MD, 1977.
  5.  Nucleic Acid Therapy in Aging and Degenerative Disease: A Metabolic Approach with DNA, RNA, and Related Metabolites, Benjamin S. Frank, 1969 (3rd ed.).
  6. A New Approach to Degenerative Disease and Aging: Effects of RNA, DNA with Other Metabolites. Dr. Benjamin S. Frank, 1964.
  7. Dr. Frank’s No-Aging Diet Cookbook, Barbara Friedlander Meyer, Marilyn Peterson, and Benjamin S. Frank, 1977.
  8. Food Healing for Man (vol. 1), Bernard Jensen, PhD, 1983.
  9. Chia: Rediscovering a Forgotten Crop of the Aztecs, Dr. Wayne Coates and Dr. Ricardo Ayerza, Jr., 2005.



The Health Benefits of Garlic

Dr. Hank Liers, PhDGarlic is one of the most effective and versatile therapeutic plants in the world with a broad range of health benefits. Indeed, it not only is a food, but also a proven medicinal herb, and supports powerful health via many modes of action. It has a long history of health-enhancing and culinary uses, making it an ideal example of a food that can be used for therapeutic purposes.

We include the use of garlic (in addition to medicinal mushrooms, echinacea, astragalus, and olive leaf extract) as a part of building powerful immunity in the HPDI Rejuvenation Program because of its effectiveness in providing the body with a highly diverse range of health benefits. For example, it acts as a powerful broad-spectrum antibiotic. It also exhibits antiviral, antifungal, and antiparasitic properties. In this regard, it has been proven to rid the body internally and externally of nearly any antigen or pathogen.

Garlic has also been found to be an Nrf2 activator and as such is able to stimulate the body’s endogenous production of key protective antioxidant enzymes (such as superoxide dismutase and glutathione peroxidase). Natural compounds normally provided by fresh garlic cloves include: alliin, allicin, thiosulfinates, gamma-glutamylcysteines, and sulfur. In addition, garlic is a rich source of organic selenium. Selenium is an important antioxidant and key component of the enzyme glutathione peroxidase.


Garlic has been used as both food and medicine in many cultures for thousands of years, dating at least as far back as when the Giza pyramids were built about 5,000 year ago. Its use in China dates back to 2000 BCE where it formed part of the daily diet, particularly when consumed together with raw meat. In Chinese medicine garlic was prescribed to aid respiration and digestion, most importantly diarrhea and worm infestation.

During Greek and Roman times, Hippocrates, Galen, Pliny the Elder, and Dioscorides all mention the health benefits of garlic for many conditions, including parasites, respiratory problems, poor digestion, and low energy. A leading physician during the latter part of the 12th century, the Abbess of Rupertsberg, St. Hildegard von Bingen, gave garlic a prominent role in her medical writing. Garlic’s antiseptic properties were verified by Louis Pasteur in 1858. The British used garlic in World War I when they ran out of sulfa drugs and during both World Wars I and II, soldiers were given garlic to prevent gangrene.

Garlic Hank Liers


In the last 50 years garlic has been the subject of over 1,000 research studies. These studies have investigated garlic’s: 1) antibiotic effect, 2) cardiovascular effects (including cholesterol lowering), 3) anticancer effect, 4) effect on blood sugar, 5) effectiveness as a heavy metal antidote, 6) potential alleviation of intestinal problems, and 7) other biological and chemical effects.

These research studies have shown that:

1) garlic lowers serum cholesterol and triglycerides while raising HDL-cholesterol,

2) garlic reduces the “stickiness” of platelets, making blood circulation more efficient,

3) garlic causes a mild reduction in blood pressure,

4) garlic is antibacterial, antiviral, antifungal, antiparasitic, and exerts action against organisms causing yeast infection,

5) regular consumption of garlic is associated with lowered risk of stomach, lung, brain, and colon cancer as well as many other types of cancer.

6) garlic is a powerful immune booster that stimulates the multiplication of infection-fighting white cells, boosts natural killer cell activity, and increases the efficiency of antibody production.


Some additional not-so-well known benefits of garlic include, 1) effectively treats hair loss, 2) clears acne, 3) prevents and treats colds, 4) soothes psoriasis, 5) helps control weight, 6) functions effectively as an aphrodisiac, 7) helps remove splinters, 8) treats athlete’s foot, 9) treats ear infections, 10) helps keep mosquitoes away, 11) treats cold sores, 12) helps fix hairline cracks in glass, 13) de-ices sidewalks, 14) can be used as a natural pesticide in the garden, and 15) can be used as fish bait.


We recommend that you consume three (or more) large cloves of fresh, organic, raw garlic every day. Garlic can be eaten raw, swallowed whole, chopped up and mixed with food, or juiced with other vegetables. The best garlic is the hottest, and, of course, organic. Raw garlic is the most therapeutic, but cooked garlic will still provide certain benefits. Garlic supplements can be used whenever fresh garlic is not available or desirable, or as adjuncts to fresh garlic. Enterically coated garlic supplements provide the highest potency and the greatest total allicin potential.

Allicin is the component of garlic responsible for most of its health benefits. Allicin is formed when the garlic enzyme alliinase comes into contact with alliin (the principal active phytochemical/component in garlic). This occurs when garlic is chopped or crushed, as occurs when chewing. The more garlic is crushed, chopped, or chewed before it’s eaten, the greater the amount of allicin is formed. In addition to chewing it well, this means it may be beneficial to use a garlic press, food processor, or other kitchen gadget to crush, mince, or finely chop the garlic before you eat it.

If (or when) you cannot consume fresh, raw garlic, then supplements can ensure you get your daily dose. In this regard, it is important to note that stomach acids destroy alliinase. This means that garlic powders (in capsules) subjected to stomach acid are ineffective. Enteric coatings that break down in the small intestine at higher pH (but not under the acidic conditions of the stomach) are required to gain maximum benefit from a garlic supplement.

If you decide to take supplements, then look for a high-quality, enteric coated garlic supplement. There are several very potent products that are convenient, easy to use, and odorless. For example, try to find a 500 mg tablet providing 6,000 mcg (minimum total allicin potential) equivalent to 1,500 mg of fresh garlic.

There are many ways to use garlic as a food. We often use garlic cloves along with other therapeutic herbs such as ginger and parsley when making  liver cleanse juices  and other vegetable juices in our juicers.

Here is one of my favorite recipes for a therapeutic pesto sauce using garlic, ginger, and parsley:


Dr. Hanks Pesto Ingredients garlic

Ginger, garlic, and parsley give Rejuvenation Pesto high nutritional value & therapeutic properties.

Our pesto recipe meets the challenge of achieving zest and flavor for salads and whole grains, and provides outstanding nutrition. Ginger and garlic are excellent foods with high sulfur and vitamin/mineral content, but they can be difficult to consume in therapeutic quantity because of their strong flavors. Parsley is often used as a garnish, but also has high nutritive value and tastes good. Marinating minced ginger, garlic, and parsley in a high-quality oil softens the bite of garlic and ginger. This pesto offers high nutrition, good color and texture, and it tastes great!


  • 1/2 lb. organic ginger root
  • 2-3 oz. organic garlic
  • 1 bunch organic parsley
  • 2 cups organic sesame oil
  • 1/4 tsp sea salt (optional)

Dr. Hank's Pesto Sauce

Directions: Prepare the ginger root by peeling the outside skin and cutting out brown spots. Peel the garlic and wash the parsley. Put the ginger, garlic, and parsley in a food processor and finely mince. Place the minced ingredients into a bowl and add the sesame oil and sea salt. Stir until well mixed and allow to marinate for 15 minutes. Serve over salad, rice, noodles, pasta or any of your other favorite grains. Do not consume too much at once because it may upset your stomach.

Other oils such as flax, safflower, sunflower, pumpkin, walnut, and olive may be used as substitutes.  Additional spices (such as curry and cayenne) may be added to change the flavor. Be creative!


For garlic recipe books see: http://www.amazon.com/s/ref=nb_sb_noss_2?url=search-alias%3Dstripbooks&field-keywords=garlic+recipe+books&rh=n%3A283155%2Ck%3Agarlic+recipe+books



Koch HP, Lawson LD, GARLIC: The Science and Therapeutic Application of Allium sativum L. and Related Species, 1996.

Jensen, Bernard, PhD. Garlic Healing Powers. Dr. Jensen’s Health Handbook Series, Vol. 8. 1992.


Ackermann RT, Mulrow CD, Ramirez G, Gardner CD, Morbidoni L, Lawrence VA. Garlic shows promise for improving some cardiovascular risk factors. Arch Intern Med. 2001;161:813-824.

Alder R, Lookinland S, Berry JA, et al. A systematic review of the effectiveness of garlic as an anti-hyperlipidemic agent. J Am Acad Nurse Pract. 2003;15(3):120-129.

Ashraf R, Aamir K, Shaikh AR, Ahmed T. Effects of garlic on dyslipidemia in patients with type 2 diabetes mellitus. J Ayub Med Coll Abbottabad. 2005;17(3):60-4.

Berthold HK, Sudhop T. Galic preparation for prevention of atherosclerosis. Curr Opin Lipidol. 1998;9(6):565-569.

Berthold HK, Sudhop T, von Bergmann K. Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism. JAMA. 1998;279.

Dillon SA, Burmi RS, Lowe GM, et al. Antioxidant properties of aged garlic extract: an in vitro study incorporating human low density lipoprotein. Life Sci. 2003;72(14):1583-1594.

Dorant E, van den Brandt PA, Goldbohm RA. A prospective cohort study on the relationship between onion and leek consumption, garlic supplement use and the risk of colorectal carcinoma in The Netherlands. Carcinogenesis. 1996;17(3):477-484.

Dorant E, van den Brandt PA, Goldbohm RA, Hermus RJ, Sturmans F. Garlic and its significance for the prevention of caner in humans: a critical view. Br J Cancer. 1993;67(3):424-429.

Durak I, Yilmaz E, Devrim E, et al. Consumption of aqueous garlic extract leads to significant improvement in patients with benign prostate hyperplasia and prostate cancer. Nutr Res. 2003;23:199-204.

Fleischauer AT, Arab L. Garlic and cancer: a critical review of the epidemiologic literature. J Nutr. 2001;131:1032S-1040S.

Fleischauer AT, Poole C, Arab L. Garlic consumption and cancer prevention: meta-analyses of colorectal and stomach cancers. Am J Clin Nutr. 2000;72:1047-1052.

Fugh-Berman A. Herbs and dietary supplements in the prevention and treatment of cardiovascular disease. Prev Cardiol. 2000;3:24-32.

Hassan ZM, Yaraee R, Zare N, et al. Immunomodulatory affect of R10 fraction of garlic extract on natural killer activity. Int Immunopharmacol. 2003;3(10-11):1483-1489.

Heron S, Yarnell E. Treating parasitic infections with botanical medicines. Altern Complement Ther. 1999;8:214-224.

Isaacsohn JL, Moser M, Stein EA, et al. Garlic powder and plasma lipids and lipoproteins: a multicenter, randomized, placebo-controlled trial. Arch Intern Med. 1998;158(11):1189-1194.

Josling P. Preventing the common cold with a garlic supplement: a double blind, placebo-controlled survey. Adv Ther. 2001;18(4):189-193.

Kannar D, Wattanapenpaiboon N, Savige GS, Wahlqvist ML. Hypocholesterolemic effect of an enteric coated garlic supplement. J Am Coll Nutr. 2001;20(3):225-231.

Koscielny J, Klubendorf D, Latza R, Schmitt R, Radtke H, Siegel G, Kiesewetter H. The antiatherosclerotic effect of Allium sativum. Atherosclerosis. 1999;144:237-249.

Levi F, Pasche C, La Vecchia C, Lucchini F, Franceschi S. Food groups and colorectal cancer risk. Br J Cancer. 1999;79(7-8):1283-1287.

Loy MH, Rivlin RS. Garlic and cardiovascular disease. Nutr Clin Care. 2000;3(3):146-151.

Mantle D, Lennard TW, Pickering AT. Therapeutic applications of medicinal plants in the treatment of breast cancer: a review of their pharmacology, efficacy and tolerability. Adverse Drug React Toxicol Rev. 2000;19(3):223-240.

Markowitz JS, Devane CL, Chavin KD, et al. Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers. Clin Pharmacol Ther. 2003;74(2):170-177.

Milner JA. A historical perspective on garlic and cancer. J Nutr. 2001;131(3s):1027S-1031S.

Munday JS, James KA, Fray LM, Kirkwood SW, Thompson KG. Daily supplementation with aged garlic extract, but not raw garlic, protects low density lipoprotein against in vitro oxidation. Atherosclerosis. 1999;143(2):399-404.

Ngo SN, Williams DB, Cobiac L, Head RJ. Does garlic reduce the risk of colorectal cancer? A systematic review. J Nutr. 2007;137(10):2264-9.

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Superko HR, Krauss RM. Garlic powder, effect on plasma lipids, postprandial lipemia, low-density lipoprotein particle size, high-density lipoprotein subclass distribution and lipoprotein(a). J Am Coll Cardiol. 2000;35(2):321-326.

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Valley Fever Supplement & Activity Program

Fred Liers PhD Valley Fever coccidiomycosis coccidiodes immitisValley Fever (Coccidioidomycosis) is a fungal disease caused by Coccidioides immitis or Coccidioides posadasii, which are fungal species endemic in areas of Arizona, California, Nevada, New Mexico, Texas, Utah, and northern Mexico. Other names for the disease include “cocci” (kok-see), “California Fever,” “desert rheumatism,” and “San Joaquin Valley Fever.”

C. immitis resides in the soil in the US Southwest (e.g., California and Arizona) and Mexico, as well as parts of Central America and South America. The fungus is dormant during long dry periods. When rains arrive, it then develops into a mold having long filaments, which break apart becoming airborne spores.

The US Centers for Disease Control (CDC) documents a 900% increase in reported cases of Valley Fever in endemic area during the period from 1998 to 2011. The number of annually reported Valley Fever cases spiked from about 2,000 to over 24,000 in a little more than a decade.

cocci valley fever spores

Coccidioides immitis

Some of the dramatic rise in Valley Fever cases probably relates to better reporting practices and more reliable testing methods. For example, it was not until 2008 that the CSTE (Council of State and Territorial Epidemiologists) case definition was revised to include cases with a single positive serologic result. And it wasn’t until 2010 that coccidioidomycosis became laboratory-reportable in California.

Still, the growth trend in reported cases of Valley Fever is alarming. The rise in diagnoses indicates how much larger the scope of the problem is than previously was known. For example, cases that were once left unreported or even misdiagnosed as pneumonia are more often now being properly diagnosed and reported.

Global warming notably has resulted in increasingly dry conditions in the US Southwest favoring the spread of C. immitis. Higher temperatures boost evaporation rates, thereby drying soils. In addition to drought, increasing atmospheric instability has led to increasing numbers of dust storms (including severe dust storms and haboobs) in Arizona (e.g., Phoenix and Yuma), New Mexico, and Texas. Such intense storms dramatically increase the spread of airborne particulates, including the spores known to cause Valley Fever.

C. immitis spores, also known as arthroconidia, become airborne whenever soil is disturbed. Activities and events disturbing soil include construction, agriculture, digging, high winds, dust storms, and earthquakes. In addition, rapid growth urban areas with high population density produce greater levels of ground disturbance (which along with other factors) adversely affect rates of incidence. Thus, Maricopa County, Arizona (including the city of Phoenix) has a surprisingly high Valley Fever incidence of about 1 in 1,125 (measured in 2007). In contrast, southern New Mexico has a ten to twenty times lower incidence rate despite also being a region where Valley Fever is endemic.

As suggested by Kenneth K. Komatsu, the state epidemiologist for Arizona, urban sprawl is a major factor because essentially you are “digging up rural areas where Valley Fever is growing in the soil” (see “A Disease Without a Cure Spreads Quietly in the West”). 13,000 cases were reported in Arizona alone in 2012. In addition, incidence rates are considered low as most cases are not reported (ADD).

Arthroconidia, as fungal spores typically produced by segmentation of pre-existing fungal hyphae (i.e., branched filamentous structures collectively known as a mycelium), are generally not as environmentally persistent as other types of spores (e.g., bacterial endospores). Nevertheless, C. immitis and C. posadasii remain medically significant pathogens due to increasingly high transmission rates of Valley Fever.

Valley Fever endemic areas USA Mexico

Valley Fever is endemic to the Southwest USA and Mexico


Spores causing Valley Fever are light-weight and are easily inhaled when airborne. Infections are caused by inhalation of particulate matter containing the spores. Valley Fever cannot be transmitted from person to person.

While C. immitis grows as a mycelium in soil, it produces a spherule form after it infects an individual. That is, upon lodging in the lungs’ alveoli, arthroconidia grow becoming spherules that develop internal septations (septated spherule). These septations form endospores. Eventual rupture of spherules release endospores, which ultimately repeat the cycle and spread the infection within the body.

Nodules may form in the lungs around a spherule. When a spherule ruptures, it can release its contents into bronchi, thereby forming thin-walled cavities. Such cavities can result in symptoms including chest pain, hemoptysis, and/or persistent cough. Also, infection can spread into the bloodstream (fungemia) in immunocompromised persons.

Fortunately, in most cases, infection with Valley Fever resolves, thereby leaving the patient with immunity to re-infection. Yet, in certain cases, infection may occur repeatedly or even become permanent.

A healthy lifestyle, diet, nutrition, and supplementing with foundational supplements and immune-fortifying formulas can greatly boost the health of the body and strengthen its immune system. When the body and its immune system are kept strong, there is not only a greater chance that an individual will avoid Valley Fever, but also a correspondent reduction of its impact upon health if or when the body contracts it.


Symptomatic infections represent just 40% of cases. Valley Fever symptoms are typically flu-like. They may include fever, cough, headaches, and rashes, as well as pains in muscles and joints.

Some patients fail to recover and develop chronic pulmonary infection or widespread “disseminated” (i.e., systemic) infection possibly affecting the meninges, soft tissues, joints, and/or bones. Not surprisingly, individuals who are immunocompromised are more susceptible to the systemic form of the infection.

As noted, most individuals infected experience no symptoms or consequences. However, serious complications can occur when patients have weakened immune systems. These complications include severe pneumonia, lung nodules, and systemic infection (as noted above). In fact, the systemic form of Coccidioidomycosis can severely damage the body, and cause skin ulcers, abscesses, bone lesions, swollen joints, heart inflammation, and other problems like meningitis.


The best way to avoid contracting Valley Fever is to prudently avoid the spores that cause it. This might mean avoiding digging in the desert. For example, use caution while preparing garden beds or doing other types of yard work (e.g., while digging ditches for laying pipe or irrigation hoses). Also, avoid being outside during periods of high winds, especially in areas where there a large amount of ground disturbance (e.g., near construction sites). This includes using prudence when exercising (e.g., running, biking, hiking) during dust storms, times of high winds, and especially in dust-prone, wind-swept areas.

Currently, recommended  measures to prevent exposure to the spores causing Valley Fever include respirator protection for persons engaged in agriculture, construction and others working outside in the endemic areas. Dust control measures such as planting grass and wetting the soil, and also limiting exposure to dust storms are advisable for residential areas in endemic areas.

haboob arizona dust storm Valley Fever spores

A wall of dust (haboob) in southern Arizona. Dust storms spread spores that cause Valley Fever.


Beyond avoiding contact with the spores that cause Valley Fever, it is vitally important to maintain a strong immune system. A strong immune system can ward off or mitigate symptoms even when the body contracts Valley Fever. Not maintaining a strong immune system can lead to full blown symptoms, illness, debilitation, and other health consequences relating to inadequate immunity (e.g., the potential for developing other health conditions). In rare cases, Valley Fever and its complications can be fatal.

Basic means for maintaining a strong immune system include proper diet, exercise, rest, and positive outlook. I will deal with a few of these basic means in greater depth below. However, the focus of this article will primarily be on dietary supplements and their role in protecting the body from Valley Fever and its effects.



One of the most basic elements for creating and maintaining optimal health is proper diet (see Rejuvenation Program). There is, in fact, no single “proper” diet for everyone. The optimal diet for an individual will depend on many factors, including age, gender, activity level, exposures to environmental toxins, food sensitivities and/or allergic responses, stress levels, blood type, genetics, and many other factors. Indeed, an optimal diet for a given individual changes over time.

carrots diet Valley Fever

That said, we recommend a varied diet high in vegetables (including greens) that provides plenty of raw foods, high-quality proteins, fiber, and complex carbohydrates (e.g., organic vegetables and fruits instead of refined, processed, and/or packaged foods). We highly recommend consuming foods that have been grown using organic and/or biodynamic methods. This helps to reduce exposure to pesticides and other agrochemicals, as well as genetically modified organisms (GMOs).


High-quality foods and a healthy diet are the basis for good health. Consuming a healthy diet, therefore, is one the first lines of defense in maintaining both health and a strong immune system that can successfully ward off diseases like Valley Fever.

Today, however, even a so-called “good” diet often does not provide adequate nutrition to keep a person healthy. There are many reasons that diet cannot typically provide all the nutrients required for optimal health. One set of reasons revolves around the fact that our food supply is compromised. These include 1) Depletion of soils over time (and the failure to re-plete them with nutrients), 2) the rise of industrial agriculture that both depletes the soil and poisons it with a cocktail of pesticides, herbicides, fungicides, and chemical fertilizers, 3) the prevalence of (and contamination of the foods supply by) genetically modified foods (GMOs) that have never been proven safe (and which studies are now showing to be harmful to health), 4) the addition of toxic additives (e.g., preservatives) to certain foods, 5) Processing and practices (such as radiation of foods) that reduce viability and nutritional value. This list could go on.

For these reasons, we at HPDI first recommend the use of four specific types of foundational supplements. The foundational supplements we recommend are: 1) a High-Potency Multivitamin providing high-quality forms of nutrients (e.g., coenzyme vitamins; minerals in Kreb cycle form like malates), 2) Super Antioxidant Formulas (that include vitamin C and Nrf2 activators) (like Ultimate Protector™ or PRO-C™), 3) Essential Fats (providing a balanced ratio of omega-3 and omega-6 fatty acids), 4) High-RNA Superfoods, especially the Rejuvenate!™ line of superfoods we have formulated for to provide therapeutic levels of dietary nucleic acids.

People sometimes ask us to offer supplement recommendations to improve their health. We have always started with the four foundational supplements. Even if a person takes no other supplements beyond these four types, they typically report better health. The reason is simple: improved nutrition equals improved health. Too often, we see individuals trying a few types of vitamins, some amino acids, a few herbs, etc. This represents an incomplete approach because it fails to address the underlying need for consistent intake of high levels of basic nutrients for which most diets do not provide.

In contrast to a seemingly random approach relying on a few targeted nutrients, we often see a “shotgun” approach in which a person attempts to take an extremely wide variety of supplements they have heard can improve their specific problem or to boost general health. This may be better than taking few (or no) supplements, but unless the body’s need for truly essential nutrients is met, a wider variety of different types of supplements may not produce optimal results.

Foundational supplements cover all the basic needs of the body. In nearly all cases, it is only after the body’s requirements for basic health are met that we begin to suggest “Enhancement” supplements that can take health to the next level (so to speak) or condition-specific supplements (e.g., Joint Health Formula) formulated to focus on the health of particular organ or body system.

For purposes of keeping the body strong in order to protect it against Valley Fever or mitigate its effects, foundational supplements remain the starting point, and by themselves will help create a high level of health.


1) MULTIVITAMINS (Select One):

Mighty Multi-Vite! (caps)

Multi Two (tabs or caps)

multi-two-120caps multi two capsules multivitamin valley fever


2) ESSENTIAL FATS (Select One):

Essential Fats Plus E

Omega Plus




Ultimate Protector™


ultimate-protector-sm ultimate protector nrf2 activator vitaminc valley fever



Rejuvenate!™ PLUS

Rejuvenate!™ Berries & Herbs

Rejuvenate!™ (original greens)

Rejuvenate! superfoods are the first superfoods formulated specifically to provide high levels of dietary nucleic acids. Dietary nucleic acids are associated with a wide range of health benefits, including greater energy (ATP) production in the body, higher tissue oxygenation, physical rejuvenation, improved stamina/endurance, cardiovascular benefits, and greater longevity and quality of life. Click here to see our Rejuvenate! Product Comparison page.

After having selected one of each of the four types of foundational formulas (including one Rejuvenate!™ superfood), you will be on your way to establishing excellent basic health. When all four types of foundational supplements are consumed daily (along with a good diet), you will be providing your body with the nutrients it needs to create powerful health and to maintain it. If you are not taking all four types of foundational supplements, then consider adding the one(s) you are missing in order to fill this gap in nutrition. You will then start to experience the power of complete foundational nutrition for creating optimal health.

All Three Rejuvenates


In the 25 years we have been in the nutritional supplement business, the vast majority of our experience shows foundational supplements truly are essential building blocks for establishing good health, as well as a point of departure on the journey toward greater health. These formulas are necessary to help to establish the excellent nutrition that subsequently acts as a base from which individuals can then discover and add additional (e.g., condition specific) formulas required for their best health. Yet, the journey always starts with the four types of foundational formulas.


Pets like dogs and cats face risks for developing Valley Fever as great or greater than humans. Pets are closer to the ground. They may dig into soils and inhale dust stirred up by their digging or windborne particulate matter. Fortunately, similar methods for improving nutrition, immunity, and means for recovery can be employed to help pets avoid Valley Fever, or fight it after they have developed it. While here is no foolproof way to prevent Valley Fever in pets, avoiding the spores, as well as maintaining good nutrition and strong immunity are vitally important.

dogs valley fever

Dogs are at particular risk for Valley Fever

HPDI offers a range of foundational supplements for pets in its 2Docs line of pet nutritional formulas. These include Pet Mighty Multi (for large pets or small pets), Pet Antioxidant Formula, Essential Fats for Pets (for large or small pets), and Rejuvenate!™ For Pets. In addition to these important foundational formulas, any of the human supplement formulas recommended (below) can be given to pets to support prevention or recover from Valley Fever. In addition, we offer 2Docs’ Cell Support For Pets, a unique formula for boosting cellular health in animals.

Visit our 2Docs page on IntegratedHealth.com to see the complete line of nutritional supplements for pets, including red line foundational supplements, blue line condition-specific formulas, and green-label superfoods (Rejuvenate!™ for Pets and Cell Support for Pets). 2Docs’ pet formulas are designed by HPDI’s formulator Hank Liers PhD and by Randy Aronson, VMD. 2Docs supplements are specifically designed to be the most effective, human-grade, pet formulas available.

Tips for keeping pets free from Valley Fever: 1) Avoid walking pets in open or undeveloped desert, 2) landscape your yard so there are groundcover plants and/or gravel/rocks (to minimize loose dirt and dust), 2) keep pets indoors during dust storms, and 3) discourage digging as the spores that cause Valley Fever can live up to one foot below the soil surface.


Immunity-building formulas are the most important supplements a person can take when seeking to prevent or mitigate the effects of a condition like Valley Fever. You can find our recommendations for immune-building supplements in our Master Rejuvenation Program. Important immunity building formulas include medicinal mushrooms (Immune-Assist™), Olive Leaf Extract, Echinacea, garlic (as a foods or supplemental form), Nascent Iodine, Vitamin D3 Plus, Astragalus, and others.


One of the most effective immune building supplements we recommend is Immune-Assist™. Immune-Assist™ contains a complex of six medicinal mushrooms containing polysaccharides providing a broad range of health benefits. This formula is a completely unique and new type of dietary supplement containing a combination of more than 200 different polysaccharides, derived from the enzymatic breakdown of complex organic plant material from six different species of medicinal mushrooms. These species include: Agaricus blazei, Cordyceps sinensis hybrid, Lentinula edodes (shiitake), Grifola frondosa (maitake), Ganoderma lucidum (Reishi), and Coriolus versicolor.

Recent scientific research has shown that medicinal mushrooms grown on vegetable sources (such as millet, rice bran, buckwheat, barley, etc.) enzymatically activate a process in which complex cross-linked polysaccharides from the vegetable sources convert to biologically active immunomodulators (known as biological response modifiers). The polysaccharides produced by this process are effective and safe immune stimulants.

shrooms1 medicinal mushrooms Valley Fever

Immune-Assist™ is similar to other mushroom-based polysaccharides in that it is formulated through an enzymatically activated process whereby complex cross-linked polysaccharides from vegetable sources are converted to biologically active immunomodulators composed of simpler sugars (such as arabinose and xylose). However, Immune-Assist™ offers significant advantages. While Immune-Assist™ contains simple polysaccharides, it also contains more complex polysaccharides, including cross-linked beta mannans and beta-glucans, and hetero-polysaccharides which combine both alpha-bound and beta-bound monosaccharides in the same molecule. These complex polysaccharide compounds are not found in earlier-generation, bran-based supplements like AHCC (Active Hexose Correlated Compound). This is the reason Immune-Assist™ shows such a greater range of immuno-modulation bioactivity than AHCC and other bran-based supplements.

This month (October 2013) Dr. Hank Liers posted an extensive blog entry on the topic of Immune Strengthening Using Medicinal Mushrooms. His article explains in detail about the beneficial effects on medicinal mushrooms. You may also be interested in our Immune-Assist™ Research Summary, which provides extensive information regarding this unique formula, and offers in-depth information regarding its uses.

Medicinal mushrooms offer unique and in many cases, unparalleled, benefits for building, re-building, and maintaining strong immune system health. Immune-Assist™ is just one such product, but due to the synergy provided by its effective combination of six different medicinal mushrooms.


Valley Fever sufferers (and individuals who wish to avoid it) can benefit from olive leaf extract. Certain extracts of olive leaf (calcium elenolate) provide significant benefits for human immunity. Olive leaf extract has a long history of use for combating illnesses in which microorganisms (including bacteria, viruses, parasites, yeast, mold, and fungi) play a role. Until 1995, however, olive leaf extracts played only a limited role for supporting the body’s fight against such microorganisms due to the fact that a protein in human blood combined with the active molecule in olive leaf extract, consequently inactivating it. It was learned in 1995 that if the active molecule in olive leaf extract were rotated around a specific axis by a precise amount, then the protein in human blood no longer inactivated the molecule. This led to the development of significantly more effective olive leaf extracts for use in supporting immunity and health.

Olive-leaf-extract olive leaf extract

The newer, more effective form of olive leaf extract has been proven effective for use in many conditions, including herpes, Epstein Barr (and cytomegalo viruses), chlamydia, cholera, hepatitis (A, B, and C), malaria, measles, meningitis, rabies, tapeworm, salmonella, tuberculosis, staphylococcus, polio, vaginitis, thrush, strep throat, whooping cough, pneumonia, ringworm, bacillus cereus, and others. For individuals hoping to avoid Valley Fever, and for those suffering from it, taking an effective olive leaf extract supports the body’s efforts to protect itself from fungal assault, and boost the immune system in ways that can help restore optimal health.

Many people report higher energy levels when using olive leaf extract. It has been shown to be extremely safe and non-toxic even in large doses. See Olive Leaf Extract by Dr. Morton Walker for further information on its effectiveness and full range of applications.

HPDI offers an Olive Leaf Extract formula that provides the most effective form of olive leaf extract.


Many studies have proven the importance of Vitamin D3 for immune system health. Well beyond the important effects on calcium and bone metabolism, Vitamin D3 provides a host of other health benefits, including the capacity to modulate innate immune system responses. Amazingly, the vitamin D receptor is expressed on immune  cells (B cells, T cells, and antigen presenting cells). It is well known that deficiency in vitamin D is associated with increased autoimmunity and increased susceptibility to infection.

Supplementing with vitamin D3 remains one of the best ways to improve vitamin D status in the body. Exposure to natural sunlight can help. However, during the winter months (and especially in northern latitudes) and/or with greater time spent indoors (e.g., in recovery), taking a high potency vitamin D3 supplement that provides at least 5,000 IU of vitamin D3 not only will support strong immunity, but will also provide many other health benefits that will support a program of prevention and/or recovery from Valley Fever.

D3Header_3 vitamin d3 plus

HPDI offers a uniquely synergistic vitamin D formula, Vitamin D3 PLUS. The formula provides 5,000 IU of vitamin D3, as well as vitamin A, vitamin K2 (as menaquinone-7), vitamin E, and tocotrienols. Vitamin D3 PLUS is an advanced formula that is designed not only to be effective, but also to work well with HPDI foundational supplements and Rejuvenate!™ superfoods.

Read more about HPDI’s Vitamin D3 PLUS. Also, see the Resources section below for articles and abstracts on the health benefits of vitamin D.


During times of illness, the body’s detoxification organs are called upon to support healing and recovery, as well as perform all their normal duties. The liver is one of the primary organs of detoxification, and performs a myriad of other functions required for good health. We recommend maintaining good liver health through the use of a milk thistle formula. We especially recommend Hepa Plus, which is a full-spectrum liver support formula.

Valley Fever taxes many different organ systems, especially when it becomes a systemic infection or persists actively for long periods of time. Hepa Plus can provide support for the liver and its functions, which are critically important for health, and especially when the body is challenged to defend itself from a fungal infection like Valley Fever.

hepa-plus-fsmall hepa plus liver formula milk thistle

Hepa Plus contains milk thistle (Silybum marianum) extract standardized to greater than 80% silymarin, dandelion root extract 4:1, alpha lipoic acid, n-acetyl-l-cysteine (NAC), thiamin diphosphate (cocarboxylase), ornithine alpha-ketoglutarate, glycine, taurine, and the minerals molybdenum and selenium.

Extensive research has shown that silymarin (the major component of milk thistle extract) exerts both a protective and a restorative effect on the liver and can stimulate the growth of new liver cells to replace old, damaged cells. Studies have shown that dandelion root enhances the flow of bile, improving such conditions as liver congestion, bile duct inflammation, hepatitis, gallstones, and jaundice.

Lipoic acid is an important nutrient that enhances metabolism, acts both as a water-soluble and fat-soluble antioxidant, and is a toxic metal chelator (including chelation of free iron, copper, cadmium, mercury, and lead). Thiamin diphosphate is a coenzyme form of Vitamin B1 and is especially helpful for impaired liver function.

NAC is an effective nutrient for increasing liver concentrations of glutathione—a critically important antioxidant in the liver. Glycine and taurine play important roles in Phase II liver detoxification pathways. Ornithine plays a key role in the urea cycle and allows the liver to eliminate the buildup of toxic levels of ammonia. Molybdenum and selenium are essential minerals for the synthesis of enzymes that support liver detoxification.

When used in conjunction with Ultimtate Protector™ formula (one of our foundational supplements), potent support is provided for nearly all important liver detoxification processes. Individuals who are suffering from Valley Fever can benefit from a liver support formula that simultaneously protects the liver, supports its function, and keeps the most important detoxification organ healthy.

Visit the Hepa Plus product page to learn more about it.


Prebiotics and probiotics play significant roles supporting immune system function and health. While we do not include probiotic formulas as part of our foundational supplement system, we suggest they be taken regularly for optimal health. When dealing with a serious illness, such as Valley Fever, it is important to provide the body with a good probiotic formula.

prescript-assist-probiotic-fsmall prescript-assist

The formula we recommend most highly is Prescript-Assist™, which is a broad spectrum probiotic and prebiotic formula. Prescript-Assist provides 29 strains of symbiotic soil-based organisms (SBOs) supporting the body’s natural intestinal balance.

For the purpose of supporting the body in dealing with Valley Fever, the primary benefits of taking a broad spectrum probiotic & prebiotic formula relate to modulation of the immune system. However, there are many other benefits to taking a high-quality probiotic formula. Benefits reported from probiotics include 1) relief of stress, anxiety, and depression, 2) mood improvement via gut-brain signaling, 3) protection against free radicals, 4) anti-inflammatory properties, 5) improvement of glucose tolerance, 6) reduction of upper respiratory tract infections, 7) allergy prevention, 8) cholesterol reduction, 9) beneficial effects in liver disease, and 10) other health benefits.

Additional health benefits of probiotics are being discovered as scientists come to understand more about how human microflora interact with soil-based organisms and other microflora in the environment. For more information about benefits of Prescript-Assist™ and other probiotic formulas, see my blog entry Prescript-Assist™ Broad Spectrum Probiotic & Prebiotic and Hank Liers entry, A New View of the Role of Bacteria in Health.

Read more about Prescript-Assist™ to learn how indispensable soil-based organisms (SBOs) can be for optimal health.


Additional nutrients that may be helpful include Nascent Iodine (8-20 drops daily on an empty stomach), Echinacea (as drops or capsules), Digestive Enzymes / Digase (2–3 caps with each meal), Garlic (fresh or enteric coated tabs–4 tabs/day), Ancient Minerals Magnesium Oil (1/4 tsp 2–3 times daily in water), Myo-Mag (2–5 caps/day-provides magnesium & malic acid), Joint Health Formula – if experiencing joint problems (6–8 capsules daily), and Selenium from l-selenomethionine (200 mcg/day).

In most cases of Valley Fever, the immune system is severely depressed, which in turn may allow for other problems such as Candida albicans infections and food allergies. It is important to reduce as many immunological challenges as possible; to take supplements which help to rebuild the immune response and strengthen the body. It is also important detoxify the body as much as possible, and to make positive lifestyle changes in the diet, exercise, stress, relaxation, etc. (see suggestions below).

The Suggested Daily Supplement Schedule (see Table 1 below) should provide a solid starting point for building or rebuilding health. However, the table and the other suggestions in this article do not necessarily represent a comprehensive program for regaining your health. You may need to do further research on Valley Fever in order to find additional sources of information that can help you given your current health status and unique situation.


As I mentioned at the beginning of this article, a good diet is vitally important for good health. Here are a few more tips for maintaining a healthy diet.

Consume a varied diet that is relatively higher in leans proteins, complex carbohydrates, and fiber, as well as relatively lower in fats and simple carbohydrates. Avoid processed/refined foods. Eat organic vegetables, fruits, whole grains (e.g., brown rice, millet, and spelt), beans, nuts and seeds (chia, sunflower, flax, pumpkin, almond, walnut and sesame in small amounts.

Try eating Hank’s Vegetable Soup several times a week. Try juicing fresh organic vegetables (e.g., carrots, celery, beets, parsley) using a juicer. Drinking 12–16 ounces of juice daily or at least a few times a week. You will see a noticeable difference in your health. Fresh juice also provides excellent nutrition for recovery and healing, and helps detoxify the body.

For non-vegetarians, good sources of lean proteins can include free-range organic meats (including beef and poultry) and small quantities of wild-caught fish (small fish are better because fish lower on the food chain tend to contain fewer toxins). Vegetarians can enjoy various high-protein organic grains (e.g., quinoa), seeds and nuts, organic (and/or raw) dairy, and limited quantities or organic, fermented soy (tempeh and tofu).

Avoid sweets (sugar), processed/refined foods (white bread and pasta), preservatives, and toxic food additives like artificial flavors and colors. Symptoms can be exacerbated by allergic reactions to the food you eat. Be observant to correlations between symptoms and the foods you have eaten. Drink purified water.


Avoid exposure to chemicals such as cleaning solvents, pesticides, paints, hairsprays and toxic cosmetics, and cigarette smoke. Also, avoid excessive exposure to gasoline fumes and diesel soot, wood smoke, gas from kitchen ranges, etc.


Exercise is always important. As you’ve probably heard many times before, it’s good for circulation of blood and lymph. It can help maintain functional strength, lung capacity, strong immunity, and brain function. Exercise also improves mood, quality-of-life, and longevity.

So be sure to get an adequate amount of exercise for you at least three times a week for 30 minutes or more. Walking, swimming, yoga, and tai chi are excellent forms of exercise. Listen to your body. Don’t overdo exercise, yet work toward greater intensity levels.

If you are currently suffering from Valley Fever and are low in energy, then be sure only to do as much exercise as you can do reasonably. As you recover, you can increase your duration and/or intensity.

Also, it is good to practice relaxation and/or stress reduction techniques daily. These can include meditation, prayer, and/or deep breathing exercises (e.g., pranayama). If you already do yoga, tai chi, qi gong, or take walks in nature, then your relaxation techniques may be built into your exercise regimen.







Ultimate Protector™

2 caps

2 caps

2 caps

2 caps

2 caps

2 caps

Take with food or snacks
Essential Fats Plus E or Omega Plus

2 softgel

2 softgel

Take with food.
Mighty Multi-Vite – Multivitamin
Multi Two tabs

2 caps

1 tab

2 caps

1 tab

Take with food.
Immune-Assist (immune-enhancing polysaccharides from organic mushroom extracts)

2 caps

2 caps

2 caps

Take with food. Take 6 caps daily for 2 weeks and then reduce to 2 caps daily. For severe cases continue with 6 caps until well.
Olive Leaf Extract

2 caps

2 caps

Take between meals if possible.
Hepa Plus

2 caps

2 caps

Take with food.

1 scoop

1 scoop

Take between meals/as snack in 6-8 oz water or juice and/or fruit.
Vitamin D3 Plus (5,000 IU)

1 softgel

1 softgel

Take 2 softgels daily for 1 month and then reduce to 1 softgel daily.
Prescript-Assist – soil based probiotic

1 cap

Take 1 capsule daily.


A Disease Without a Cure Spreads Quietly in the West (NY Times)

Valley Fever: Alternative Medicine (Valley-Fever.org)

Valley Fever Connections (Valley-Fever.org)

Systemic Mycoses: An Overview for Natural Health Professionals
(Dr. Robert Thiel); The Original Internist, Sept. 2010, Vol. 17 (3): 119–128

Hot, Dry Winds Help Spread Deadly Valley Fever Infections (video) (PBS NewHour)

Valley Fever: California’s Silent Epidemic (NBC Bay Area)


Immune Strengthening Using Medicinal Mushrooms – Hank Liers

Vitamin D3 – “Superstar”! – Hank Liers

Vitamin D3 for Health: A New Review Article by Dr. Michael Holick – Fred Liers

A New View of the Role of Bacteria in Health – Hank Liers

Prescript-Assist™ Broad Spectrum Probiotic & Prebiotic – Fred Liers


Potential Immune Benefits of Strong Vitamin Status in Healthy Individuals (Science Daily)

Vitamin D Crucial to Activating Immune Defenses (Science Daily)


A Valley Fever Case Study | Odin’s Story


Vitamin D and the Immune System (J Investig Med. 2011 August; 59(6): 881–886)

Probiotic Bacteria in the Human Gastrointestinal Tract as a Factor Stimulating the Immune System (Postepy Hig Med Dosw. 2009 Dec 23;63:653-67)

Cross-Talk Between Probiotic Bacteria and the Host Immune System (J Nutr. 2007 Mar;137(3 Suppl 2):781S-90S)

Probiotics: Effects on Immunity (Am J Clin Nutr. 2001 Feb;73(2 Suppl):444S-450S)


Immune Strengthening using Medicinal Mushrooms

Dr. Hank Liers, PhDA healthy immune system is required for rejuvenation. Yet, often it is the immune system itself that requires rejuvenating to bring it to a level where it can better support rejuvenation of the entire body. Our Rejuvenation Program therefore builds the immune system and includes supplement recommendations and supporting protocols to accomplish that goal. The most important immune building supplement we recommend is Immune-Assist™, a mushroom complex of six medicinal mushrooms containing polysaccharides that provide a wide range of health benefits.

Other important immune building supplements included in HPDI’s Master Rejuvenation program are echinacea, garlic, olive leaf extract, and astragalus. We will discuss immune strengthening using medicinal mushrooms and Immune-Assist™ in this article. Additional articles (forthcoming) will be dedicated to the other immune-building supplements.

Medicinal Mushrooms Extracts: One of the Most Powerful Immune Modulators

Recent scientific research has shown that medicinal mushrooms grown on vegetable sources (such as millet, rice bran, buckwheat, barley, etc.) enzymatically activate a process whereby complex cross-linked polysaccharides from the vegetable sources are converted to biologically active immunomodulators (also known as biological response modifiers). As you will see from the discussion below, the polysaccharides produced by this process are effective and safe immune stimulants.



Medicinal mushroom research has focused on discovering compounds that can positively or negatively modulate the biological response of immune cells. Certain mushroom derived-glucans and polysaccharide-bound proteins have been shown to act as immunomodulators or biological response modifiers (BRMs). A variety of therapeutic effects often occur when these mushroom-derived polymers interact with the immune system to upregulate or downregulate specific aspects of the responses of the host. Whether certain compounds enhance or suppress immune responses can depend on a number of factors including dosage, route of administration, timing and frequency of administration, mechanism of action, or the site of activity.

Many mushroom-derived polysaccharides appear to fit the accepted criteria for BRM compounds. They cause no harm and place no additional stress on the body, they assist the body to adapt to the various environmental and psychological stresses, and they have a non-specific action on the body, supporting all the major systems, including nervous, hormonal, and immune systems, as well as regulatory functions.

The anti-tumor polysaccharides isolated from mushrooms (fruit-body, submerged, cultured mycelial biomass or liquid culture broth) are either water-soluble β-D-glucans, β-D-glucans with heterosaccharide chains of xylose, mannose, galactose, or uronic acid or β-D-glucan-protein complexes – proteoglycans.

While the role of medicinal mushrooms in immunomodulation and anti-cancer activities represents the central theme of much of the conducted research, it is pertinent to observe that many of the medicinal mushrooms have been highly valued for other medicinal properties including hypercholesterolemia, high blood pressure, diabetes, anti-viral, anti-bacteria, and antioxidant and free radical scavenging.

Mushroom-Derived β-glucans are Safe

The safety criteria for mushroom-derived β-glucans have been exhaustively carried out in pre-clinical experiments. Acute, subacute, and chronic toxicity tests have been carried out together with administration during pregnancy and lactation with no adverse effects. There were no anaphylactic reactions and no effects in mutagenicity and haemolysis tests, blood coagulation and a wide range of other regulatory tests.

There was no evidence of genotoxicity. Similar results have been obtained with other β-glucans. When applied to humans in Phase 1 clinical tests, the β-glucans demonstrate remarkably few adverse clinical reactions.

Therapeutic Properties of Medicinal Mushrooms

In the 2001 report Medicinal Mushrooms: Their Therapeutic Properties and Current Medical Usage with Special Emphasis on Cancer Treatments, a wide variety of mushroom polysaccharides, including Lentinan (from L. edodes), Schizophyllan (from S. commune), PSK and PSP (from Trametes versicolor), and Grifron-D (from the Maitake mushroom G. frondosa) and others are described, and their properties are shown to satisfy the criteria for BRMs.

Many of these mushroom-derived polymers potentiate the host’s innate (non-specific) and acquired (specific) immune responses in a similar manner, where they activate many kinds of immune cells that are vitally important for the maintenance of homeostasis. Key innate responses that are stimulated by these mushroom derived-β-glucans or polysaccharide-protein complexes include host T-cells (such as cytotoxic macrophages, monocytes, neutrophils, natural killer cells, and dendritic cells) and chemical messengers (cytokines such as interleukins, interferon and colony stimulating factors) that trigger complement and acute phase responses.

Moreover, mushroom polysaccharides or polysaccharide-protein complexes are considered as multi-cytokine inducers that are able to induce gene expression of various immunomodulatory cytokines and cytokine receptors. In addition, acquired responses are also enlisted, where lymphocytes that govern antibody production (B cells) and cell-mediated cytotoxicity (T-cells) are stimulated. While the immune system is shrouded in tremendous complexity, our current understanding shows that it is regulated in an orchestrated dynamic manner.

Mushroom-derived polysaccharides have shown anti-tumour activities in both pre-clinical models and in clinical trials. Although the mechanism of their anti-tumour action is still not completely clear, Lentinan, Schizophyllan, PSP, PSK and other mushroom polysaccharides appear to mediate their anti-tumour activity by activation or augmentation of the host’s immune system (via stimulated cytotoxic macrophages, cytotoxic T-cells and antibody-mediated cytoxicity of targeted cancer cells), rather than direct cytotoxicity.

Thus, both cell-mediated immune responses against the target T-cells initiated by macrophage-lymphocyte interactions and cytoxicity induced by antibodies to target T-cells are believed to contribute to the elimination of targeted tumour cells. Recent evidence suggests that several mushroom polysaccharides may also possess cytotoxic properties. Grifron-D from G.fondosa mushroom was reported to induce apoptosis (programmed cell death) in human prostate cancer cell-lines.

IMMUNE-ASSIST™ Incorporates Polysaccharide Extracts from Six Organically Grown Medicinal Mushrooms

In China, Japan, Korea, and more recently in the US, hundreds of mushroom species have been studied during the past 20 years. Extracts from most of the medicinal mushrooms show a common property of enhancing immune function by modulating cell-mediated immunity. Simply put, such mushroom extracts seem to turn on cells in the immune system, which appear to have significant disease-fighting properties. In fact, three different anticancer drugs extracted from mushrooms have been approved by the Japanese equivalent of FDA (that is, the Japanese Health and Welfare Ministry). These three are lentinan, derived from shiitake; PSK, derived from coriolus versicolor; and schizophyllan, derived from suehirotake.

Based upon a a large amount of research, a US-based company has formulated Immune-Assist™ , which includes a combination of more than 200 different polysaccharides, derived from the enzymatic breakdown of complex organic plant material from six different species of medicinal mushrooms. These include Agaricus blazei, Cordyceps sinensis hybrid, Lentinula edodes(shiitake), Grifola frondosa (maitake), Ganoderma lucidum (reshi), and Coriolus versicolor.

Immune-Assist™ contains simple polysaccharides similar to many other products on the market, but it also contains much more complex polysaccharides like the cross-linked beta mannans and beta-glucans, as well as hetero-polysaccharides which combine both alpha- and beta-bound monosaccharides into the same molecule. This is the reason that Immune-Assist™ shows such a greater range of immuno-modulation bioactivity than other bran-based supplements. Included among the important substances in Immune-Assist™ are Arabinoxylane, Lentinan, Grifolan (Dr. Nanba’s original Maitake D-Fraction), PSK and PSP, and Active Hemicellulose Correlated Compound (AHCC).

Below we provide a brief summary of the research and clinical studies for each of the mushrooms contained in Immune-Assist™:

Shiitake is now the most popular and most cultivated exotic mushroom in the world. In China, shiitake has a history that dates back to the Ming Dynasty (1368–1644 ACE). The mushroom was used not only as a food but was taken as a remedy for upper respiratory diseases, poor blood circulation, liver trouble, exhaustion and weakness, and to boost chi, or life energy.  It was also believed to prevent premature aging.  Today the shiitake is recognized for its antitumor action and has been extensively researched in regard to its immunologic activity. The initial antitumor research was performed in 1969 by Tetsuro Ikekawa at Purdue University, along with colleagues at the National Cancer Center Research Institute in Tokyo. The researchers found that water extracts of shiitake produced high rates of tumor inhibition in mice (72–92%). Ikekawa later identified a polysaccharide in shiitake called lentinan as having powerful antitumor activity.

Coriolus (or Trametesversicolor is the most thoroughly clinically researched mushroom. An extract of Coriolus versicolor known as PSK is sold in Europe and Japan. It is the best-selling cancer drug in the world and recently accounted for more than 25% of Japan’s total national expenditure for anticancer agents. In addition to possessing many different antitumor properties, it is also an immunostimulant; demonstrates anti-viral activity; enhances T-cell proliferation; and has been shown to improve both disease-free and survival rates in cancer patients. In an 8-year clinical test of breast cancer patients, and in another 5-year study, it was shown that the polysaccharide compounds contained within Coriolus versicolor work particularly well as an adjuvant for cancer therapies, exhibiting diverse biological activities.

Maitake may be even more potent than any of the other mushrooms previously studied. This legendary giant mushroom has been studied for its anticancer, anti-diabetic, anti-hypertensive and anti-hyperlipemic effects since the mid-1980s. Its anti-HIV activity in vitro was demonstrated in tests conducted by the Japan Institute of Health and the US National Cancer Institute in early 1992. Among various extracts obtained from the Maitake mushroom, a specific extracted fraction named Maitake D-fraction is the active constituent. This extract contains beta-1, 3-glucans and beta-1, 6-glucans protein-bound polysaccharides. It has demonstrated remarkable antitumor activity by activating the immune system through oral administration.

The Chinese people have long used Cordyceps sinensis to promote overall good health, and modern research indicates that it does indeed support liver, kidney, heart, and immune system function. Cordyceps sinensis has been used to protect the bone marrow and digestive systems of mice from whole body irradiation. One experiment noted that Cordyceps may protect the liver from damage. An experiment with mice indicated the mushroom may have an anti-depressant effect. Researchers have observed that Cordyceps has a hypoglycemic effect and may be beneficial for people with insulin resistance. Cordyceps mushroom extracts have been shown to stimulate the number of T helper cells, prolong the survival of lymphocytes, enhance TNF-alpha and interleukin 1 production, and increase the activity of natural killer cells. One study indicates that cordyceps can stimulate progesterone production in animal cells. Another study has shown that cordyceps may be effective against tumor cells by down-regulating MHC class II antigen expression. In addition, historical use data suggests that cordyceps can cause a reduction of cyclosporin and aminoglycoside-induced renal toxicity.

Reishi possess anti-tumor, immunomodulary, and immunotherapeutic activities, supported by studies on polysaccharides, terpene, and other bioactive compounds isolated from fruiting bodies and mycelia of this fungus. It has also been found to inhibit platelet aggregation, and to lower blood pressure (via inhibition of angiotensin-converting enzyme), cholesterol and blood sugar. Laboratory studies have shown anti-neoplastic effects of fungal extracts or isolated compounds against some types of cancer. In an animal model, Reishi has been reported to prevent cancer metastasis, with potency comparable to Lentinan from shiitake mushrooms. The mechanisms by which Reishi affect cancer may target different stages of cancer development include: 1) inhibition of angiogenesis (formation of new, tumor-induced blood vessels created to supply nutrients to the tumor) mediated by cytokines, 2) cytotoxicity, 3) inhibition of migration of the cancer cells and metastasis, and 4) inducing and enhancing apoptosis of tumor cells. Besides effects on mammalian physiology, Reishiis reported to have anti-bacterial and anti-viral activities. Reishi is reported to exhibit direct anti-viral effects with the following viruses: HSV-1, HSV-2, and influenza.

Agaricus blazei is an edible mushroom native to Brazil and cultivated in Japan and the USA for its medicinal uses. It has been used to treat arteriosclerosis, hepatitis, hyperlipidemia, diabetes, dermatitis, and cancer. In vitro experiments and studies done in mice have shown that Agaricus has immunomodulatory, antitumor, and antimutagenic properties. The polysaccharides and anti-angiogenic compounds present in Agaricus are thought to be responsible for its antitumor properties. Such effects are believed to be exerted by immunopotentiation or direct inhibition of angiogenesis. A recent randomized study showed that oral administration of Agaricus extract improved the natural killer cell activity and quality of life in gynecological cancer patients undergoing chemotherapy. Agaricus was also shown to have antidiabetic effects in vitro and in animal studies. In addition, results from a study done in human subjects with type 2 diabetes suggest benefits of Agaricus extract in improving insulin resistance, and a pilot study indicates that Agaricus extract may reduce weight, BMI, body fat, and serum glucose and cholesterol levels in healthy individuals.

AHCC as a Component of Immune-Assist™ Daily Formula

AHCC is produced by from the enzymatic action of vegetable sources with mycelial extracts from several different mushrooms. There is about four times more AHCC in each dose of Immune-Assist™ than there is in other AHCC products on the market.

AHCC is a food substance that contains a broad range of polysaccharides. It is believed that a special polysaccharide with a molecular weight of about 5,000 and an alpha 1,4 glucan linkage in this mushroom extract is primarily responsible for the powerful immune enhancing effects on natural killer cells. A heavier polysaccharide in the extract appears to have a powerful stimulating effect on macrophages which, in turn, further stimulates the immune system including a number of cytokines (Interleukin-2, Interleukin-12, Tumor Necrosis Factor [TNF], and Interferon).  Furthermore, some research has indicated that components of AHCC may have direct cytotoxic effects on cancer cells and prevent metastases from occurring.

Natural Killer Cells

The human immune system is comprised of more than 130 subsets of white blood cells. Natural Killer (NK) cells make up roughly 15% of all human white blood cells. They provide the first line of defense for dealing with any form of invasion to the body. Each NK cell contains several small granules that act as chemical destroyers. Once an NK cell has recognized a cancer cell, for example, it attaches itself to the cell’s outer membrane and injects these granules directly into the interior of the cell. The granules then destroy the cancer cell within five minutes. The undamaged NK cell then moves on to other cancer cells and repeats the process. When the immune system is particularly strong, active NK cells will often take on more than one cancer cells or other infected cells at the same time.

NK Cell Activity, Not Number, Determines Immune System Strength

Unlike other white blood cells, inadequate numbers of NK cells are very rarely a problem. Instead, it is the activity of the cells that generally determines whether one is sick or healthy. As long as the NK cells are active, everything remains under control. If NK cells lose their ability to either recognize or destroy the invader, however, the situation can deteriorate rapidly. In AIDS and cancer patients, NK cell activity is probably the primary criteria for estimating the chances of survival. It’s commonly accepted that when NK cells cease to function, the end is near.

In addition, research has now confirmed that individuals with low NK cell activity are significantly more susceptible to autoimmune diseases, chronic fatigue syndrome, viral infections and the development of cancerous tumors.

Doctors can test NK cell activity with a test called the NK cell function test. Basically, a blood sample is taken from the patient and placed in a vial containing live tumor cells. After four hours, a count is taken to determine what percentage of the cancer cells have been destroyed by the NK cells. The higher the percentage, the more active the cells. This test is referred to as the 4 hour Chromium-release assay. Your doctor can order the test from Immune Sciences Lab in Beverly Hills, CA at 310-657-1077.

How IMMUNE-ASSIST™ Increases NK Cell Activity and Immunity

The capacity of Immune-Assist™ to boost NK activity and overall immunity appears to stem from the following:

1) Immune-Assist™ increases the number of explosive granules in NK cells. The more granules an NK cell carries, the more cancer and virus-infected cells it can destroy,

2) Oral ingestion of Immune-Assist™ can increase NK activity as much as 300% (or even higher),

3) It increases interferon (IFN) levels. Interferon is another potent compound produced by the body that both inhibits the replication of viruses and other parasites and increases NK cell activity,

4) Immune-Assist™ increases the formation of Tumor Necrosis Factors (TNFs). TNFs are a group of proteins that help destroy cancer cells,

5) It increases number and the activity of other lymphocytes, especially T-cells (up to 200%) and macrophages,

6) It stimulates cytokine (IL-2, IL-12, TNF, and IFN) production, which stimulates immune function.

Applications for Immune-Assist™

Applications for Immune Assist™ include: 1) recurrent infections, such as colds, flu, and parasites, 2) gum disease, 3) heart disease, 4) peptic ulcer, 5) cancers, 6) slow healing wounds, 7) digestive problems, 8) AIDS, 9) hepatitis, 10) multiple sclerosis, and 11) autoimmune illnesses. Immune Assist™ has not exhibited side effects and is completely non-toxic even after years of use at therapeutic levels.

Owing to its tremendous immune enhancing effects, Immune-Assist™ is likely to be of significant benefit to individuals suffering from a wide range of conditions. Impaired immunity is a result of a wide range of poor lifestyle habits including high stress levels, exposure to high levels of toxins, and poor nutritional status.  As such individuals in the following categories could also benefit from Immune Assist™:

  • Individuals who constantly work with paint (artists, house painters, etc)
  • Chemical and refinery workers and others exposed to heavy doses of toxic chemicals
  • Heavy smokers
  • Heavy drinkers
  • Individuals with gum disease
  • Individuals with peptic ulcers
  • Individuals with prostate infections
  • Individuals with chronic fatigue syndrome
  • Individuals with diabetes
  • Individuals with heart disease
  • Individuals experiencing autoimmune deficiencies (multiple sclerosis, lupus, rheumatoid arthritis)
  • Individuals with recurrent infections, such as colds, flu, yeast, and parasites
  • Individuals whose families exhibit a significant history of cancer
  • Individuals with slow healing wounds

Immune-Assist™ Dosages

Immune AssistThe dosages used in studies are scientifically based on repeated NK cell activity tests. As such, they are consistent and easy to follow. They fall into two types:

1) For cancer, HIV or other life-threatening condition, take three grams per day for two-to-four weeks, then one gram per day until the problem is resolved. Some people continue to take the maintenance dosage even after the problem has been resolved, while others stop taking it and resume if the problem returns. In rare cases taking as much as six grams daily was necessary.

2) As a form of prevention take one gram per day.

In all of the studies, it has been found that taking 3 grams a day resulted in a dramatic increase in NK cell activity within one to two weeks. At the lower dosage of only one gram per day, the same activity wasn’t reached until about four weeks. Thus, the initial heavy doses of three grams per day.  Even after the dosage is dropped back to one gram per day, NK cell activity will continue to increase.  It is best to take the Immune-Assist™ capsules with meals in divided doses.  For example, when taking three grams per day (which works out to six 500 mg capsules), two capsules can be taken with each meal. When you reduce the dosage down to one gram a day (two capsules), you can take one capsule at breakfast and one at dinner.


The importance of a strong, adaptable immune system cannot be underestimated, especially in the context of building (or rebuilding) health and for successful rejuvenation. While there are other useful immune building supplements (e.g., echinacea, garlic, olive leaf extract), Immune Assist™ is highly effective for boosting immunity as part of a complete program for rejuvenation.

Learn more about Immune-Assist™ on the HPDI website.


1) Healing Mushrooms by Dr. Georges Halpern, MD, PhD., 2007, https://www.academia.edu/20332538/Healing_Mushrooms_by_Georges_Halpern

2) Medicinal Mushrooms: their Therapeutic Properties and Current Medical Usage with Special Emphasis on Cancer Treatments. 2001

Authors: JOHN E SMITH BSc MSc PhD DSc FIBiol FRSE Emeritus Professor of Applied Microbiology, University of Strathclyde Chief Scientific Officer, MycoBiotech Ltd, Singapore. NEIL J ROWAN BSc MSc PhD MIBiol MIFST Lecturer, Department of Bioscience, University of Strathclyde, RICHARD SULLIVAN BSc MD PhD Head of Clinical Programmes, Cancer Research UK.

To download this book go here:

3) Anti-Cancer Properties: A peer-reviewed article by Dr. Solomon Wasser of University of Haifa, Israel: Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides